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University of Massachusetts Chan Medical School

Job in Worcester, Worcester County, Massachusetts, 01609, USA
Listing for: BRIC
Full Time position
Listed on 2026-10-23
Job specializations:
  • Research/Development
    Research Scientist, Immunology Research
Salary/Wage Range or Industry Benchmark: 90000 - 125000 USD Yearly USD 90000.00 125000.00 YEAR
Job Description & How to Apply Below

University of Massachusetts Chan Medical School

University of Massachusetts Chan Medical School

366 Plantation Street, DiMare:

N9-1029, Worcester, MA 01605, USA

1. Genetic medicine development for chronic inflammatory and musculoskeletal disorders
  • Design and carry out experiments to understand the molecular mechanisms by which dysregulation of immune cells, bone cells, dental pulp cells, and muscle cells causes chronic inflammatory diseases (i.e., rheumatoid arthritis, osteoarthritis, autoinflammatory diseases), prevalent skeletal diseases (i.e, osteoporosis, impaired fracture healing, heterotopic ossification), dental diseases (osteonecrosis of jaw, periodontitis, tooth implantation), bone metastatic cancers, skeletal rare diseases (Fibrodysplasia Ossificans Progressiva, Osteogenesis Imperfecta), and musculoskeletal diseases (i.e,

    spinal muscular atrophy).
  • Design and carry out experiments to develop potential genetic medicine using recombinant adeno-associated virus (rAAV) and/or RNA therapeutics (i.e, miRNA, siRNA, ASO).
2. Others
  • Oversee technician and students working on related projects.
  • Prepare oral presentations for program/department research in progress meetings, submit abstracts for poster and oral presentations at national/international meetings.
  • Write up research results for publication.
Requirements:
  • PhD in Molecular and Cellular Biology, Immunology, Bone Biology, Gene Therapy, or related discipline.
  • Hands-on laboratory experience in relevant methodologies, trouble-shooting technical problems, and data analysis skills are required;
  • Experience in the following techniques preferred: DNA cloning, cell culture, qPCR, immunoblotting, enzyme-based immunoassays, histology for bone and/or soft tissues, immunohistochemistry, immunofluorescence, confocal microscopy, database comparisons.
  • Outstanding organizational and time management skills, as well as the ability to communicate in English and work both independently and as part of a team in a fast-paced environment.
  • The position includes opportunities for project and career development, interaction with a diverse, talented and collegial immunology community at UMMS.

UMass Medical Center is an equal opportunity employer.

To apply for this position:

Contact Dr. Jae-Hyuck Shim, Professor of Genetic and Cellular Medicine, Horae Gene Therapy Center, Li Weibo Rare Disease Research (jaehyuck.shim)

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