Principal Scientist

Title:

Principal Scientist Company:

Ipsen Biopharm Ltd About Ipsen:
Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas:
Oncology, Rare Disease and Neuroscience. Supported by nearly 100 years of development experience, with global hubs in the U.S., France and the U.K, we tackle areas of high unmet medical need through research and innovation. Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries.

We build a workplace that champions human-centric leadership and fosters a culture of collaboration, excellence and impact. At Ipsen, every individual is empowered to be their true selves, grow and thrive alongside the company’s success. Join us on our journey towards sustainable growth, creating real impact on patients and society! For more information, visit us at  and follow our latest news on Linked In and Instagram.

Job Description:

Principal Scientist - Cell Line Development & Upstream Process Development

Location:

Wrexham, UK (Hybrid Working)

Contract:

Permanent Travel:
Occasional travel (European) Shape the Future of Biologics at Ipsen At Ipsen, we're passionate about advancing innovative medicines that make a meaningful difference to patients' lives.

As Principal Scientist, you will act as a recognised subject matter expert, leading the development and optimisation of cell line and upstream manufacturing processes for biologic products from candidate selection through to commercial manufacturing. A key focus of the role will be driving upstream process development activities using mammalian and/or microbial cell lines, supporting multiple development programmes while providing technical leadership and mentorship to junior scientists.

You will play an integral role within cross-functional CMC teams, partnering with internal stakeholders and external Contract Development and Manufacturing Organisations (CDMOs) to ensure successful programme delivery. This position offers exposure to a diverse biologics pipeline and the opportunity to influence development strategy across multiple projects while collaborating with colleagues throughout Ipsen's global organisation.

• Lead Cell Line Development and Upstream Process Development strategies across biologics development programmes.
• Provide scientific leadership for CMC development projects from early development through commercialisation.
• Act as a subject matter expert for CLD and USP activities, supporting technical decision-making across programmes.
• Drive innovation and continuous improvement to enhance process productivity, robustness and product quality.
• Represent Upstream Process Development within multidisciplinary CMC teams.
• Collaborate with internal stakeholders and external CMOs to support development, scale-up and technology transfer activities.
• Contribute to regulatory submissions and technical documentation.
• Conduct technical assessments for new product opportunities and in-licensing activities.
• Mentor, coach and develop junior scientists, fostering a culture of scientific excellence.

We're looking for a scientifically driven leader with strong biologics development experience and the ability to influence across complex, matrixed environments.

• Significant pharmaceutical or biotechnology industry experience within biologics development.
• Deep expertise in Cell Line Development and/or Upstream Process Development.
• Strong experience working with CHO cell lines and mammalian cell culture processes.
• Experience leading CMC development activities across the product lifecycle.
• Proven ability to work effectively with cross-functional stakeholders and external…