Head of Mass Spectrometry

Responsibilities

• Lead the day-to-day operations of the MS platform, including scheduling, quality control and sample throughput across metabolomics, isotope tracing and other MS-omics workflows.
• Drive method development for LC-MS/MS-based stable isotope tracing, metabolomics, RNA modifications and lipid analysis, including applications to in vivo and patient-derived samples.
• Ensure high data quality, robust data management and fully reproducible workflows through rigorous QC and precise documentation.
• Co-develop and implement automated sample preparation workflows to increase throughput and improve reproducibility.
• Co-design data acquisition and processing infrastructure around Orbitrap Astral instruments.
• Maintain mass spectrometry instruments at the highest performance standards and manage service contracts and consumables.
• Contribute to the development of single-cell mass spectrometry methods as part of the lab's technology agenda.
• Actively contribute to research projects, from experimental planning and data interpretation through to manuscript writing.
• Train and mentor graduate students, postdocs and collaborators in MS techniques and experimental design.
• Advise on and support procurement of future equipment and contribute to grant applications for infrastructure funding.
• Represent the platform in internal and external collaborations across the Zurich life sciences community.

• Expert (MSc or PhD) in analytical chemistry, biochemistry or a closely related field with a strong mass spectrometry track record.
• Hands‑on expertise with high‑resolution LC‑MS platforms, ideally including Orbitrap‑based instruments.
• Proven experience in stable isotope tracing and/or metabolomics in a biological research context.
• Demonstrated ability to develop and optimize analytical methods from first principles.
• Experience with or strong interest in laboratory automation – liquid handling systems, automated sample prep, or workflow scripting.
  • Interest in or experience with single‑cell mass spectrometry technologies is a plus.
  • Experience mentoring or teaching MS techniques to non‑specialists.
  • Strong publication record showing independent scientific contributions.
  • Experience running or co‑running a core or research facility is a strong plus, not prerequisite.
  • Fluent in English;
    German is an asset but not required.

Yigit Baskan
HR Business Partner

yigit.baskan.ch