Senior Principal Scientist, Immune Cell Depletion Discovery Group, Immunology Discovery Research

Job Description

The Immunology Discovery Therapeutic Area is seeking an accomplished and experienced Scientist to lead the Immune Cell Depletion Group within the Immune Reset Therapeutics Discovery team based in Cambridge, MA. In this role you will lead a multidisciplinary team of highly talented scientists with experimental, technical and scientific expertise in cellular depletion approaches. The candidate should have a demonstrable track‑record in this scientific discipline alongside a strong knowledge of preclinical drug discovery spanning target discovery/validation through to GLP toxicology phases.

You will collaborate and deliver results across multi‑disciplinary line functions both internally and with external leading experts. Proven experience leading preclinical drug discovery programs leveraging cellular depletion approaches in autoimmune disease is an advantage. Applicants should have a strong publication record and proven experience in leading (managing) and developing bench‑based scientists.

• Lead the Immune Cell Depletion Group within Immunology Discovery and refine strategy and biology focus to support and advance the portfolio.
• Provide biology expertise to internal teams that helps pave the way for next‑generation therapies that leverage cell depletion approaches for rheumatological, dermatological, gastroenterological and respiratory diseases.
• Serve as a key member of the Immune Reset Therapeutics Discovery Leadership Team, supporting the advancement of Immune Tolerance biology into the drug discovery pipeline.
• Manage, grow, and develop highly talented scientists.
• Drive performance by Leading from the Bench, designing and executing key experiments to inform GO/NO‑GO decision points at critical project stages.
• Lead and influence early to late‑stage discovery programs.
• Apply deep immunology expertise, focusing on how cell depletion approaches can raise the treatment ceiling for patients with autoimmune disease.
• Develop and execute a strategy aligned with functional goals and key scientific objectives in discovery immunology research.
• Collaborate as a highly team‑oriented, considerate professional, and be responsive to the needs of others.
• Communicate effectively, both verbally and in writing, and make data‑driven decisions.
• Provide expert advice and share knowledge with direct reports, peers, and senior leadership.
• Establish and manage external collaborations with leading research labs worldwide, including attendance and presentation at conferences and publication submission.

• 18+ years (BS), 16+ years (MS), or 10+ years (PhD) of related work experience in academia, biotech or pharma.
• Extensive experience in immunology drug discovery within a high‑caliber research environment with 6+ years of related experience in biotech or pharma.
• Ability to create an inclusive environment where diverse ideas, viewpoints, and backgrounds are valued, and willingness to lead inclusively.
• Ability to work, influence, lead, and deliver results in cross‑functional teams.
• Excellent written, presentation, and interpersonal communication skills, effective in a highly collaborative environment.

• Builds strong relationships with peers and partners to enable high performance.
• Learns quickly, grasps the essence, and can change course rapidly when needed.
• Raises the bar and is never satisfied with the status quo.

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors, including geographic location, and may ultimately be higher or lower than the posted range.
  
  This range may be modified in the future.
• We offer a comprehensive package of benefits, including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and a 401(k) plan to eligible employees.
• This job is eligible to participate in our long‑term incentive programs.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled.