Senior Scientist I (In Vivo Pharmacology

Position: Senior Scientist I (In Vivo Pharmacology)
## Senior Scientist I (In Vivo Pharmacology)
Apply locations:
Alameda, CAtime type:
Full time posted on:
Posted Yesterday job requisition :
JR7007
** SUMMARY/JOB PURPOSE** **(Basic purpose of the job):
** The Senior Scientist I is responsible for supporting in vivo pharmacology research efforts for various Biotherapeutics projects.  The strong candidate must be a highly self-motivated, interactive, and productive hands-on PhD scientist. This individual will possess strong knowledge and hands-on experience with various animal models in cancer biology and immuno-oncology and be able to strategically incorporate the latest technologies into Pharmacology functions.

The candidate must have a deep understanding of the concept of PK, PD, and efficacy, and be able to interpret their relationship.
** ESSENTIAL DUTIES/RESPONSIBILITIES:
*** Lead, design, execute and interpret in vivo pharmacology (PK/PD/Efficacy) experiments to test the selected compounds in rodent tumor models.
* Hands-on in vivo work is required with support for external CRO studies when needed.
* Represent the Pharmacology function on Biotherapeutics project teams.
* Provide scientific support for the project teams and Biotherapeutics/Translational Pharmacology staff.
* Utilize literature and internal data sets to design and test hypotheses for drug targets.
* Prepare Pharmacology study reports for research findings and support IND filings.
* Collaborate with the IACUC committee to ensure compliance with internal policies and animal welfare regulations.
*
* SUPERVISORY RESPONSIBILITIES:

*** None.
** EDUCATION/EXPERIENCE/KNOWLEDGE &

SKILLS:

*
* Education:

* BS/BA in Pharmacology, Cancer Biology, Molecular Cellular Biology or related field and a minimum of 7 years relevant experience; or,
* MS/MA in Pharmacology, Cancer Biology, Molecular Cellular Biology or related field and a minimum of 5 years relevant experience; or,
* PhD in Pharmacology, Cancer Biology, Molecular Cellular Biology or a closely related field and 0 years of relevant experience; or,
* Equivalent combination of education and experience.

Experience:

* Deep understanding of in vivo Pharmacology (PK, PD and efficacy) concepts for oncology drug discovery including I-O biology and related drug mechanisms.
* Extensive experience using in vivo tumor models for drug discovery with a proven track record in hands-on establishment, validation, and implementation of animal models for testing cancer therapies, including xenograft, syngeneic, genetically engineered mouse, orthotopic, PDX and humanized models to study biologic mechanisms.
* Proven track record of writing regulatory and IND filing documents in the pre-clinical Pharmacology section.
* Proven track record of good experimental design, in-depth data analysis and interpretations based on strong scientific rationale.
* Expertise in cell culture with aseptic technique and basic in vivo techniques (handling different routs of administration, blood collection, etc.) is a must.
* Strong scientific expertise with a good track record of publications.
* Experience working with CROs to coordinate and execute studies in a timely manner.
*
* Knowledge, Skills and Abilities:

*** In vivo skills including, but not limited to, animal handling, dosing with different routes (po, iv, sc, ip, im, etc.), blood collection, tissue collection/perfusion, necropsy, tumor measurement, clinical observation, and rodent survival surgeries.
* Solid biological and mechanistic understanding of biologics in oncology and immune-oncology including specific and specialized readouts and protocols for in vivo studies.
* Understanding the regulations and guidelines of IACUC and AAALAC is a must.
* Has flexibility to adapt to a fast-paced work environment and coach junior scientists.
* Excellent oral and written communication and presentation skills.
* Detail-oriented and able to problem-solve and offer potential solutions.
* Strong communication skills, excellent work ethic, self-motivation and ability to work effectively either in a team environment or independently.
* Advanced knowledge of MS Office, .pdf, Graph Pad, Benchling notebook, and Studylog is required.
** Work Environment/Physical…