Associate Principal Scientist, Systems Biology

Associate Principal Scientist, Systems Biology Skip to main content
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Not Applicable locations:
USA
- Pennsylvania
- West Pointtime type:
Full time posted on:
Posted Todaytime left to apply:
End Date:
July 10, 2026 (14 days left to apply) job requisition :
R404055
** Job Description
** ASSOCIATE PRINCIPAL SCIENTIST –  SYSTEMS BIOLOGY  The Vaccines & Advanced Biotechnologies department, part of our Research & Development Division, is looking for a
** passionate and talented systems biologist
** with expertise in the generation and analysis of complex multi-dimensional and multi-scale biological data to join our research team and support our Company’s discovery & development efforts at West Point, PA. In this role, you will be at the very leading-edge of therapeutic research and development, developing and implementing experimental and computational tools in a dynamic and scientifically rigorous environment.

You will operate in a highly collaborative and matrixed organization and engage with cross-functional teams of experimental and computational biologists, data scientists, and colleagues across our Company's ecosystem to drive a diverse therapeutic pipeline. The successful candidate will be a scientifically curious team player and self-motivated learner with previous knowledge of functional genomics-driven experimental strategies at the bulk and single-cell scales and an interest in developing and using technology solutions (algorithms/tools/etc) to aid in our interpretation of complex biological data.

An ability to communicate clearly and collaborate effectively with colleagues from different disciplines will be essential.  This role is based at our West Point, PA location.  In this exciting role, you will:
* Directly contribute to multiple stages of therapeutic development through rigorous design and/or implementation of high-dimensional functional genomics and cellular profiling assays, including
* in vitro
* and
* in vivo
* pooled/arrayed CRISPR screens, single-cell transcriptomics and lineage tracing, as well as experimental and
* in silico
* derived proteomic datasets.
* Perform statistically rigorous quantitative analyses while employing reproducible research and data integrity practices on large-scale biological datasets.
* Analyze, interpret, and summarize complex biological data and employ data visualization tools to facilitate communication of findings to broader audiences.
* Identify, analyze, and integrate internal and external data and knowledge resources to enable data mining in a biological context and inform actionable learnings to drive pipeline development.
* Develop and implement experimental and/or computational methods to integrate findings from functional genomics screens and other data sets (including RNA-Seq, DRUG-seq, WGS, CRISPR, single cell RNA-Seq, proteomics, and metabolomics) with additional biological data streams to generate deep biological knowledge and drive innovation. REPRESENT SYSTEMS BIOLOGY EXPERTISE IN CROSS-FUNCTIONAL TEAMS:
* Provide clear interpretation of high-dimensional data and propose candidates for further computational and biological interrogation.
* Engage with cross-functional teams to translate biological hypotheses into experimental and/or computational interrogations of functional…