Associate Principal Scientist, Systems Biology

ASSOCIATE PRINCIPAL SCIENTIST – SYSTEMS BIOLOGY

In this role, you will develop and implement experimental and computational tools and collaborate cross-functionally to drive therapeutic pipeline discovery and development at West Point, PA.

• Contribute to therapeutic development via high-dimensional functional genomics / cellular profiling assays, including pooled/arrayed CRISPR screens, single-cell transcriptomics & lineage tracing, and proteomic datasets.
• Perform statistically rigorous quantitative analyses with reproducible research / data integrity on large-scale datasets.
• Analyze, interpret, and visualize complex biological data for broader audiences.
• Integrate internal / external data and knowledge resources to enable biological data mining and actionable learnings.
• Develop / implement experimental and/or computational methods to integrate multi-omics (RNA-Seq, DRUG-seq, WGS, CRISPR, scRNA-Seq, proteomics, metabolomics) to generate biological knowledge.

Required:

• Ph.D. in Systems Biology, Computational Biology, Computer Science, Biostatistics, Genetics, Immunology, Mathematics, Molecular Biology, Statistics, or related + 4 years experience.
• Demonstrated experience with experimental and/or computational strategies interpreting large-scale biological data (e.g., sequencing modalities, pooled / arrayed CRISPR screens).
• Fluency generating / analyzing NGS datasets (RNAseq, WES, scRNAseq, spatial transcriptomics).
• Experience with statistical hypothesis testing and machine learning.
• Experience integrating multi-omics sources and biological knowledge bases.

Preferred:

• Knowledge of algorithm tradeoffs for DNA-seq / RNA-seq / scRNA-seq / functional genomics.
• Familiarity with public repositories / databases and extracting biological insights; strong publication record.

• R (incl. Shiny / tidyverse), Python, MATLAB for statistical analysis and interpretable visualizations.
• Cell culture; RNA / DNA extraction; sequencing library prep; experimental design.
• HPC / AWS;
  Linux;
  Git / Git Hub; adapt to analytic frameworks.

Salary range $142,400–$224,100; eligible for annual bonus and long-term incentive (if applicable); medical, dental, vision, 401(k), paid holidays and vacation, compassionate and sick days.

Application:
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