Principal Scientist, Cancer Immunology Clinical Translational Research

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

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The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome.

We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.

We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Summary:

We are seeking an experienced immunologist with clinical translational experience to join the Translational Research team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, engaged, and creative scientist that can thrive in a highly matrixed organization to advance programs from candidate optimization through IND enabling activities and ultimately to Proof-of-Concept clinical trials.

This individual will play a pivotal role in shaping and driving translational strategies for oncology assets, enabling the development of transformative cancer therapies for patients.

Position Responsibilities:

In the role as a Principal Scientist within Translational Research, the ideal candidate:

* Serve as a key scientific stakeholder in early clinical trial programs.

* Design and develop biomarker, pharmacodynamic, and target engagement assays to understand drug mechanism of action and response.

* Interact with project teams and contract laboratories for the design, execution, and oversight of molecular, cellular, and/or in vivo studies.

* Collaborate with cross-functional teams and external partners (CROs, specialty labs) to generate high-quality biomarker data for clinical studies.

* Contribute to translational plans, sample collection strategies, and documentation for early-phase trials.

* Present experimental results and share scientific insights with project teams and stakeholders.

* Proactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles, as well as input around tumor types and potential impact of biomarkers on internal decision making.

* Provides oversight to progress validated biomarkers into development of diagnostic assays, as needed

* Participates in strategic review and input to presentations, publications and internal/ external communications along with accountable program leadership and in governance forums

* Develops solutions and courses of action for senior staff, including identification of risks and risk mitigations

* Shares expertise, experience, lessons learned and knowledge with translational and other relevant scientific experts and colleagues across the organization

Experience =

Basic Qualifications:

* Bachelor's Degree

* 8+ years of academic and / or industry experience

Or

* Master's Degree

* 6+ years of academic and / or industry experience

Or

* Ph.D. or equivalent advanced degree in the Life Sciences

* 4+ of academic and / or industry experience

Preferred Qualifications:

* PhD and 6+ years of industry experience in drug development, ideally with at least 3 years in clinical…