Senior Product Manager, Oncology

Remote | Bay Area, CA or Austin, TX
- Must be located near a Natera laboratory with the ability to commute onsite a few times per month.
About the Role:

The Senior Product Manager, Oncology leads product development and commercial scale for Signatera, Natera's market-leading tumor-informed minimal residual disease (MRD) assay. This role owns laboratory turnaround time, throughput, and process stability across core lab sites. You will drive the change control review (CCR) pipeline end-to-end from root-cause investigation through requirements authorship, core team leadership, and post-launch hypercare monitoring.

As the product lead for lab process performance, you will leverage operational and sequencing data, build capacity and financial models for equipment and automation investments, and serve as the subject matter expert to Software Engineering and Digital Product Management on instrument integration and LIMS requirements. This is an analytical, data-first, execution-heavy role for someone who bridges technical change control, product requirements, SQL queries, and lab floor operations.

• Own and execute the product roadmap for future Signatera features and service components.
• Write clear requirements that balance clinical customer needs with lab throughput realities.
• Build data-backed business cases and financial models for equipment, automation, and operational improvements.
• Run the change control process end-to-end: root cause analysis, requirements, board review, hypercare, and close-out.
• Define quantitative product performance indicators, track operational datasets, and drive systematic process improvements across teams.
• Establish go/no-go criteria and hypercare metrics for new feature launches, maintaining ownership through exit criteria.
• Conduct VOC interviews, market research, and competitive intelligence to validate product features and fuel market growth.
• Partner with product marketing to define positioning, pricing, and technical launch collateral.
• Communicate vision, roadmap progress, and technical updates clearly to cross-functional stakeholders.

• Bachelor’s degree in life sciences, physical sciences, statistics, or engineering. Master’s or PhD preferred.
• Minimum 5 years of professional experience, including 2-3 years in product management, commercialization, or strategic consulting within diagnostics, medical devices, or oncology.
• Experience with products delivered as laboratory services strongly preferred.
• Demonstrated experience driving data-driven process improvements using operational data and VOC to eliminate failure modes across the sample lifecycle.
• Hands-on experience with quality systems (CAPA, nonconformance, change control) in a CLIA/CAP lab environment preferred.
• Experience with SQL, Snowflake, Statistical Process Control (SPC), or continuous improvement frameworks (Lean, Six Sigma) preferred.

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

• Annual performance incentive bonus
• Long-term equity awards
• 401(k) with company match
• Generous paid time off and company holidays
• Additional wellness and work-life benefits

Compensation Range

$154,600—$190,300 USD

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted…