Research Associate II​/Senior Research Associate

The Role

Generate Biomedicines is seeking a Research Associate II/Senior Research Associate to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting‑edge structural biology, contributing to our mission of accelerating drug discovery through advanced imaging technologies.

• Perform protein purification, complexation, vitrification, and clipping, ensuring high-quality sample preparation for CryoEM.
• Load and operate CryoEM microscopes, executing data collection with automated workflows.
• Collaborate with multidisciplinary teams to support high-throughput protein structure determination.
• Follow standard operating procedures (SOPs) and contribute to process optimization.
• Document experimental data and report findings in internal databases.
• Interpret and troubleshoot experimental data, contributing to planning and prioritization of concurrent CryoEM experiments.
• Apply and refine data analysis methods; determine reliability of results and communicate findings in presentations or team meetings.
• Contribute to process optimization and implementation of new protocols.

• MSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field and 0‑2+ years of experience, or a BSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field with 2‑4+ years of related experience.
• Hands‑on experience in basic wet‑lab techniques, including pipetting, buffer preparation, and protein purification.
• Strong understanding of protein chemistry concepts, such as molarity, protein concentration, and buffer formulation.
• Ability to work in a fast‑paced, collaborative research environment.
• Strong attention to detail and ability to troubleshoot technical issues.

• Familiarity with structural biology techniques and CryoEM sample preparation.
• Prior exposure to CryoEM workflows or microscope operation with Serial
  
  EM.

• You’re excited to learn fast and build deep expertise in CryoEM and structural biology—this role offers hands‑on training with advanced instrumentation, real ownership of experiments, and the chance to grow your technical skillset alongside experienced scientists.

On‑site position at our Andover, MA CryoEM lab

Andover, MA (On‑site, 5 days/week)

We are a clinical‑stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large‑scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein‑based medicines. Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities.

By unifying computational design and clinical development within a single operating model, we translate this approach into clinical‑stage programs and are leading a shift from traditional drug discovery toward systematic drug generation. At Generate:

Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:

Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job‑related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range

• $85,000—$111,000 USD