Principal Scientist – Protein Formulation & Biophysical Characterization; -Concentration Bi

Position: Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Bi[...]
Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Biologics)
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United States - Massachusetts - And overtime type:
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Vandaag geplaatstjob requisition :
4956789
** Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Biologics)
** is a hands-on, laboratory-focused, scientific leadership role within a biologics and vaccines formulation group (DPDD
- PhRD) for a deeply technical scientist driving innovation in protein formulation and high-concentration biologics.

The role focuses on developing and implementing novel formulation strategies and platform approaches to enable high-dose, patient-centric biologic delivery, including subcutaneous administration.

The successful candidate will generate mechanistic insights and translate them into scalable solutions that enhance Pfizer’s drug product capabilities.

The individual will serve as a technical subject matter expert, contributing across cross-functional teams and building external scientific presence through publications, presentations, and participation in industry collaborations and consortia.
** Key Responsibilities
***
* 1) Formulation Science & Characterization
*** Design and execute experimental studies to develop and optimize protein formulations across biologic modalities (e.g., mAbs, fusion proteins, bispecifics, antibody-drug conjugates, peptides, etc.) in liquid and lyophilized dosage forms.
* Apply biophysical and physicochemical characterization to assess and mitigate key risks (e.g., aggregation, viscosity, stability).
* Analyze data, generate clear insights, and communicate findings to scientific teams.
*
* 2) Innovation & Technology Development
*** Develop and advance novel formulation strategies and enabling technologies for high-concentration biologics.
* Build scalable approaches such as experimental workflows, screening methods, and predictive tools that can be applied across programs.
* Collaborate with cross-functional teams to implement and integrate new technologies.
*
* 3) External Scientific Engagement
*** Build collaborations with academic and industry partners to advance formulation science.
* Contribute to external scientific visibility through publications, conference presentations, and participation in industry consortia.
*
* 4) Cross-Functional Contribution
*** Collaborate with the internal Device Center of Excellence to facilitate optimal device selection, serving as a liaison and technical subject matter expert on formulation matters.
* Provide formulation expertise to project teams and support key development decisions.
* Contribute scientific input to regulatory documentation as needed.
*
* 5) Technical Leadership
*** Lead a cross-functional group focused on subcutaneous delivery of biologics. Align with key stakeholders and devise and implement strategies to advance the biologics portfolio.
* Lead focused technical initiatives or platform problems; prior experience with formal project leadership is preferred but not required.
** Education & Experience
*** PhD in Pharmaceutics, Pharmaceutical Sciences, Biophysical Sciences, Biochemistry, Chemistry, Biomedical  or Chemical Engineering, or related disciplines with 3–5 years relevant experience in biologics formulation, biophysics, or drug product development (industry experience preferred)
* Demonstrated scientific output (e.g., publications and/or conference presentations) preferred
** Must Have
*** Strong background in protein formulation for parenteral biologics
* Direct hands-on experience with biophysical/analytical characterization techniques and data interpretation including proficiency with a broad suite of techniques (DLS, DSC, DSF, SEC-MALS, NTA, CD, FTIR, fluorescence spectroscopy, rheology); ability to design and interpret multi-technique characterization studies
* Familiarity with parenteral dosage forms and delivery…