Principal Scientist – Protein Formulation & Biophysical Characterization; -Concentration Bi

Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Biologics)

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

The role focuses on developing and implementing novel formulation strategies and platform approaches to enable high‑dose, patient‑centric biologic delivery, including subcutaneous administration. The successful candidate will generate mechanistic insights and translate them into scalable solutions that enhance Pfizer’s drug product capabilities. The individual will serve as a technical subject matter expert, contributing across cross‑functional teams and building external scientific presence through publications, presentations, and participation in industry collaborations and consortia.

• Design and execute experimental studies to develop and optimize protein formulations across biologic modalities (e.g., mAbs, fusion proteins, bispecifics, antibody‑drug conjugates, peptides, etc.) in liquid and lyophilized dosage forms.
• Apply biophysical and physicochemical characterization to assess and mitigate key risks (aggregation, viscosity, stability).
• Analyze data, generate clear insights, and communicate findings to scientific teams.

• Develop and advance novel formulation strategies and enabling technologies for high‑concentration biologics.
• Build scalable approaches such as experimental workflows, screening methods, and predictive tools that can be applied across programs.
• Collaborate with cross‑functional teams to implement and integrate new technologies.

• Build collaborations with academic and industry partners to advance formulation science.
• Contribute to external scientific visibility through publications, conference presentations, and participation in industry consortia.

• Collaborate with the internal Device Center of Excellence to facilitate optimal device selection, serving as a liaison and technical subject matter expert on formulation matters.
• Provide formulation expertise to project teams and support key development decisions.
• Contribute scientific input to regulatory documentation as needed.

• Lead a cross‑functional group focused on subcutaneous delivery of biologics. Align with key stakeholders and devise and implement strategies to advance the biologics portfolio.
• Lead focused technical initiatives or platform problems; prior experience with formal project leadership is preferred but not required.

• PhD in Pharmaceutics, Pharmaceutical Sciences, Biophysical Sciences, Biochemistry, Chemistry, Biomedical or Chemical Engineering, or related disciplines with 3–5 years relevant experience in biologics formulation, biophysics, or drug product development (industry experience preferred).
• Demonstrated scientific output (e.g., publications and/or conference presentations) preferred.

• Strong background in protein formulation for parenteral biologics.
• Direct hands‑on experience with biophysical/analytical characterization techniques and data interpretation, including proficiency with a broad suite of techniques (DLS, DSC, DSF, SEC‑MALS, NTA, CD, FTIR, fluorescence spectroscopy, rheology); ability to design and interpret multi‑technique characterization studies.
• Familiarity with parenteral dosage forms and delivery considerations.
• Ability to analyze complex data and communicate clear, actionable insights.

• Demonstrated expertise in protein design/engineering principles, structure‑function relationship, identification of develop ability hot spots, and how molecular attributes influence formulation behavior.
• Deep understanding of challenges at elevated protein concentrations: viscosity, self‑association, aggregation, LLPS, colloidal instability, opalescence; familiarity with interaction parameters (kD, B22).
• Knowledge of subcutaneous drug delivery fundamentals: injection volume/concentration constraints, tissue interactions, injectability, bioavailability considerations,…