Senior Scientist I, Biotherapeutic Production Technologies

The Role

The Role:

Location:

Andover, MA Generate:

Biomedicines is seeking an experienced Senior Scientist I to independently lead complex protein production and characterization efforts in support of drug discovery and platform initiatives. This individual-contributor role will work across upstream construct and expression strategy, mammalian and cell-free protein production, downstream purification, and fit-for-purpose analytical characterization. You will define technical approaches, integrate data across workflows, and make recommendations that enable confident scientific decisions across multiple protein modalities and stages of work.

You will serve as a technical point of contact for protein purification and characterization strategy, partnering with cross-functional teams and external collaborators to align material quality, scale, timelines, and downstream requirements. You will also help advance scalable, data-rich workflows that improve throughput, reproducibility, and organizational learning. Here’s how you will contribute:
Independently define, plan, and execute complex protein production, purification, and characterization strategies across multiple discovery and platform initiatives. Establish technical milestones, decision criteria, dependencies, and risk-mitigation plans. Lead the design, optimization, scale-up, and troubleshooting of protein expression workflows, including transient mammalian and cell-free protein synthesis platforms. Provide technical input into construct design, molecular biology, and stable-expression activities as needed. Lead purification workflow development from capture through polishing, with particular emphasis on larger-scale or later-stage protein production.

Design and interpret chromatography screening studies, including predictor-plate approaches, resin selection, operating-condition optimization, and scale translation. Produce high-quality protein material across a range of formats and scales.

Partner with downstream stakeholders to establish fit-for-purpose quality attributes and acceptance criteria based on intended use. Select, apply, and interpret appropriate analytical and biochemical characterization methods to assess protein purity, identity, concentration, oligomeric state, aggregation, stability, and other relevant quality attributes. Integrate expression, purification, and characterization data to identify root causes, resolve complex technical challenges, evaluate trade-offs, and recommend next steps.

Clearly communicate the evidence, assumptions, risks, and uncertainty supporting technical decisions. Serve as a technical point of contact for protein production, purification, and characterization strategy. Influence cross-functional decisions by translating scientific findings into clear recommendations for discovery, platform, analytical, and data-focused partners. Lead technical interactions with CROs, CDMOs, vendors, and other external partners as appropriate, including defining technical work packages, supporting method or process transfer, reviewing data, troubleshooting issues, and ensuring that deliverables meet scientific requirements.

Drive the development of scalable, reproducible, and well-documented workflows. Advance the thoughtful use of automation, high-throughput approaches, structured experimental data, and AI/ML-enabled tools to improve scientific productivity and learning. Develop and share new methods, technical standards, and best practices. Advise and mentor colleagues, provide constructive scientific feedback, and contribute to an inclusive, collaborative, and high-performing team. Demonstrate accountability for scientific quality and delivery by tracking progress, proactively surfacing risks, and communicating successes, setbacks, and lessons learned with clarity and transparency.

Independently define, plan, and execute complex protein production, purification, and characterization strategies across multiple discovery and platform initiatives. Establish technical milestones, decision criteria, dependencies, and risk-mitigation plans. Lead the design, optimization, scale-up, and troubleshooting of…