Principal Ultrasound Engineer

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Full Time Professional Ann Arbor, MI, US

Salary Range: $ To $ Annually

Histo Sonics is a commercial-stage medtech company advancing the Edison® System, a novel non-invasive sonic beam therapy based on histotripsy. Since receiving FDA De Novo grant for the non-invasive destruction of liver tumors in 2023, the company has progressed beyond initial market entry into commercial expansion, reimbursement momentum, and ongoing clinical and pipeline development. In addition to its current liver tumor indication, Histo Sonics is pursuing future indications across multiple applications including kidney, pancreas, prostate, neuro, women’s health, and other significant underserved human health areas, to realize the broader potential histotripsy across multiple disease states and medical specialties.

We offer an exciting work culture where cutting-edge science meets real-world application, and each team member’s contribution is important to our success in ensuring our physicians and their patients get what they need most.

Ann Arbor, MI;
Madison, WI or Plymouth, MN

Histo Sonics is seeking a Principal Ultrasound Engineer to own diagnostic ultrasound image quality across our histotripsy platforms. You will work across two programs in parallel: a next-generation platform in active R&D, where you will develop B-mode image optimization algorithms and drive advanced imaging modes including color and power Doppler; and the Abdominal Edison System, where you will serve as an imaging subject matter expert improving image quality during histotripsy treatment alongside our ultrasound imaging partner.

This is a hands-on role. You will prototype, implement, and quantitatively validate imaging algorithms, and set technical direction for external ultrasound partners. Success is measured by demonstrable improvement in the clarity, consistency, and clinical utility of the images physicians rely on to target, guide, and monitor therapy. The role reports to the Associate VP of Research and Advanced Development and is expected to operate with a high degree of independence.

• Design, prototype, and validate B-mode image optimization algorithms — speckle reduction, edge detection and enhancement, adaptive filtering, compounding, and dynamic range and gain management.
• Own the definition, specification, and acceptance of advanced imaging modes, including color and power Doppler — implementing directly where appropriate, and otherwise driving delivery through a beam former OEM partner and independently verifying performance against acceptance criteria.
• Serve as the imaging subject matter expert during histotripsy treatment, tuning imaging performance for targeting, real-time visualization, treatment monitoring, and post-treatment assessment.
• Establish objective image quality methodology — contrast, contrast-to-noise ratio, resolution, penetration, SNR, frame rate, and Doppler sensitivity — using phantoms, tissue models, and clinical data, and convert it into acceptance criteria that carry through design verification.
• Set technical direction for external ultrasound OEM and imaging partners, including transducer, beamforming, and front-end system requirements; review implementations, independently evaluate delivered image quality, and drive partner work to program objectives.
• Investigate and resolve imaging artifacts and degradation arising from concurrent therapy delivery, including therapy/imaging synchronization and cavitation-induced clutter.
• Own imaging-related…