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AI Engineer - Metabolic Sensor Design

Job in Ashburn, Loudoun County, Virginia, 22011, USA
Listing for: Howard Hughes Medical Institute (HHMI)
Full Time position
Listed on 2026-01-24
Job specializations:
  • Engineering
    AI Engineer, Software Engineer
Job Description & How to Apply Below
Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147##
** Intro:
** AI@HHMI: HHMI is investing $500 million over the next 10 years to support AI-driven projects and to embed AI systems throughout every stage of the scientific process in labs across HHMI. The AI initiative will be centered at HHMI’s Janelia Research Campus. Janelia has been at the forefront of AI-driven research in biology for more than 15 years. Its forward-thinking structure, centralized funding, and collaborative culture make it ideally suited to take this bold leap forward.

To learn more about the initiative, visit .
** Also, please include a link to your Git Hub profile and/or links to relevant projects at the bottom of your cover letter.
** The Combin

AItorial Sensor Design project is part of HHMI’s AI for Science Initiative () and brings together expertise in protein engineering, advanced microscopy, and machine learning. Our goal is to develop a protein biosensor optimization pipeline that integrates high-throughput functional screening with predictive deep learning to accelerate the directed evolution of protein biosensors for visualizing dynamic biochemical processes in living cells.
** What we provide:
***
* What you’ll do:

*** Develop and maintain computational infrastructure and predictive tools for AI biosensor optimization, including tool development for modeling fluorescence properties and biochemical performance from sequence and structure
* Design and execute rigorous comparative experiments between model architectures.
* Collaborate with other team members to ensure seamless integration of computational and experimental aspects of the project.
* Apply machine learning, AI techniques, and software engineering best practices to deliver scalable, maintainable, and reproducible AI systems for protein engineering.
* Carefully document data, code, and processing pipelines to enable seamless reproduction and extension of research results.
* Actively contribute to the latest advancements in the field and continuously improve your skillset with the latest advances in AI research and technologies.
* Collaborate with interdisciplinary teams, potentially mentor junior engineers, and direct or assist in directing the work of others to meet project goals while advising stakeholders on data strategies and best practices.
*
* What you bring:

***
* Physical Requirements:

** Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).Persons

with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
*
* Please Note:

** This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the

Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.
* Compensation Range
* AI Engineer II: $ (minimum) - $  (midpoint) - $ (maximum)
AI Engineer III: $ (minimum) - $ (midpoint) - $ (maximum)
AI Engineer IV: $ (minimum) - $ (midpoint) - $ (maximum)

Pay Type:

Salary

HHMI’s salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal consistency when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.**#LI-BG1
**** Compensation and Benefits
** Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional…
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