Bioprocess Associate – Downstream

Aruna Bio is a clinical-stage biotech company advancing a new class of cell-free biologics — exosomes — for the treatment of central nervous system and neurodegenerative disorders. We're looking for a Bioprocess Associate 1 – Downstream to join our manufacturing team and support production of AB126, our lead therapeutic exosome candidate.

As a Downstream Bioprocess Associate I you'll be executing established downstream bioprocess workflows and purifications in a cGMP environment. We need someone with solid hands‑on lab skills, disciplined documentation habits, and the ability to work independently within defined protocols.

• Perform downstream bioprocess workflows, including TFF systems, chromatography, and fill‑finish, per established protocols and cGMP standards
• Support and occasionally participate in upstream bioprocess workflows via basic supply preparations, formulations, and documentation for mammalian cell culture
• Follow aseptic technique practices to preserve both research and clinical material integrity
• Operate production equipment (pipettes, balances, biosafety cabinets, incubators, autoclaves, microscopes, centrifuges) accurately and safely
• Maintain safety standards and lab upkeep (includes routine disinfections of bioprocessing spaces and certain equipment)
• Complete manual, cGDP‑compliant documentation in batch records and forms with a high degree of accuracy
• Routine database updates/maintenance for downstream performance data (Excel, JMP, Prism, etc.)

• Associate degree with a minimum of 2 years of experience in a relevant field (e.g. bioprocessing, chemistry, biology); or a bachelor's degree in a relevant field plus 1 year of relevant research experience
• Previous academic experience in TFF purification.
• Working knowledge of basic chemical and biological safety procedures in a lab setting
• Excellent organizational, time management, and written and oral communication skills
• Strong attention to detail, especially pertaining to data records
• Demonstrated ability to work independently with limited supervision, showing personal accountability
• Proficiency with primary Microsoft Office Suite tools (Outlook, Microsoft Word, PowerPoint, Excel)
• Ability to work cooperatively in a controlled environment (ISO 5, 7, and
  8) wearing clean room PPE for extended periods of time
• Willingness to participate in a rotating weekend work and holiday schedule to perform primary cell culture maintenance tasks
• Hands‑on industrial experience in a cGMP‑compliant environment (Preferred)
• Previous experience operating pilot or commercial‑scale chromatography, TFF, or other purification technologies (Preferred)