Macromolecular X-ray Crystallography Facility Manager; Research Scientist

Macromolecular X-ray Crystallography Facility Manager (Research Scientist; 50%)

Job Summary: The Facility Manager will oversee daily operations, instrument maintenance, and user support for the Macromolecular X-ray Crystallography Core Facility at the University of Colorado Anschutz Medical Campus, while providing hands‑on scientific expertise in biomolecular crystallography.

• Manage and operate the Core Facility, overseeing X‑ray diffraction instrumentation, crystallization robotics, and ancillary equipment to ensure safe, reliable, and efficient operations.
• Provide hands‑on scientific expertise in biomolecular crystallography, including crystallization, crystal screening, X‑ray data collection, data processing, structure determination, and model building to support funded biomedical research projects.
• Maintain and coordinate instrumentation and service needs, including routine instrument care, coordination with service engineers, and management of service contracts for highly specialized X‑ray and crystallization equipment.
• Train, supervise, and support facility users, onboarding them in the safe use of X‑ray diffraction and crystallization robotics, and providing scientific guidance on experimental design and data interpretation.
• Manage facility data, computing, and administrative operations, including data storage and backup, basic Linux‑based system administration, maintenance of user records, scheduling, and chargeback/billing processes.
• Contribute to the broader structural biology research environment by assisting with reports and grant applications, facilitating collaborations, and interacting with related core facilities such as cryo‑EM and NMR.

• MS in Structural Biology, Biochemistry, Chemistry, Physics, or a closely related field.
• Demonstrated hands‑on experience in macromolecular X‑ray crystallography, including crystallization, data collection, and data processing.

• Advanced experience with macromolecular X‑ray crystallography instrumentation, including diffraction systems, detectors, cryogenic equipment, and crystallization robotics.
• Experience supporting or working in a shared core facility environment, including user training, scheduling, or instrumentation coordination.
• Proficiency with computational tools for data analysis and management in a structural biology setting (e.g., Linux‑based systems, data processing pipelines).

• Knowledge of X‑ray crystallography techniques and use of highly specialized equipment.
• Ability to interact well with faculty, students, postdoctoral fellows, and staff.
• Excellent organizational skills.
• Ability to operate, maintain, and support shared scientific instrumentation in a research or core facility environment, including training and supporting multiple users.

Onsite – Aurora, CO.

Submit a letter of interest and a résumé/CV, and five references through the University of Colorado careers portal at

The University of Colorado is an Equal Opportunity Employer and complies with all applicable federal, state, and local laws governing nondiscrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity, and we encourage individuals from all backgrounds to apply, including protected veterans and individuals with disabilities.

We provide reasonable accommodations to applicants with disabilities throughout the application process. To request accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator coordinator.

CU Anschutz strongly encourages vaccination against COVID‑19 and other vaccine‑preventable diseases. If you work in certain research areas or perform safety‑sensitive duties, you may be required to enroll in an occupational health medical surveillance program.

Background investigations are conducted for all prospective employees.

Annual salary range: $40,000 – $50,000. This position is not eligible for overtime compensation unless it is non‑exempt.