Post-Doctoral Fellow – Forester Laboratory

Post-Doctoral Fellow – Forester Laboratory

This position reports directly to Craig Forester, MD, PhD, and will work within the Forester Lab, a component of the School of Medicine's Pediatric Hematology, Oncology and BMT. This position is involved in studies aimed at understanding the role of transcriptional gene regulation in hematopoietic stem cells and mutations found in pediatric bone marrow failure. Specifically, the Fellow will help investigate the role of Taspase1 mutations in early hematopoietic failure.

The Fellow is expected to conduct research projects, to think independently, be highly motivated, design and carry out experiments, analyze data, and interpret and publish results. It is the Fellow's responsibility to fully understand the technical details of Dr. Foresters' projects as well as how each applies within the larger context of defining novel therapeutic agents in Hematological Research and broadening our understanding of mechanisms underpinning pediatric marrow failure.

Key Responsibilities:

• Design and Performance of Research Experiments (75% of Time Spent)
• Mechanism based discovery of aberrant transcription in pluripotent tissues.
• Characterization of hematopoietic differentiation from iPSCs.
• Use of animal model systems to study hematopoietic engraftment.
• Engage in self-directed work with bioinformatic core to develop expertise in analysis of nascent transcription, CUT&Run and protoeomics (if not already proficient)
• Analysis and Publication of Research Data (20% of Time Spent)
• Mentoring of students and technical staff (5% of Time Spent)
• Prepare data and manuscripts for publication
• Prepare grant proposals to obtain independent post-doctoral funding
• Actively participate in and present data at group meetings, journal clubs and conferences
• Work in conjunction with the PI and other lab staff to achieve programmatic goals, including student supervision
• Other duties as assigned

To fulfill job requirements, candidates must receive training and adhere to institutional standards of best practice in: animal care and handling, radiation and chemical safety, laboratory safety and other areas as determined by the institution and/or PI.

Work Location:

Onsite – this role is expected to work onsite and is located on the Anschutz Medical Campus in Aurora, Colorado.

The Department of Medicine, Hematology/Oncology/Bone Marrow Transplant Laboratories, at the University of Colorado Anschutz Medical Campus (CU-AMC), is looking for a bright, creative and enthusiastic Post-Doctoral Fellow interested in advancing their career in a high-impact laboratory headed by an energetic, principal investigator, Dr. Craig Forester. The lab is part of a richly collaborative interdisciplinary group of basic scientists and clinicians from immunology, hematology and molecular biology backgrounds with significant resources.

The University of Colorado offers a comprehensive benefits package. To see what benefits are available for Post-Doctoral Fellows, please visit:

Minimum Qualifications:

• A doctoral level degree (PhD, MD, MD/PhD) in immunology, stem cell biology, experimental hematology, molecular biology, cancer biology or equivalent from an accredited institution.
• At least one first-author publication in an internationally recognized, peer-reviewed journal.

Conditions of Employment:
Candidate must be able to work with laboratory animals and animal tissues. Candidate must meet eligibility requirements for NIH T32 and F32 postdoctoral fellowship awards.

Preferred Qualifications:

• Graduate training in a biomedical laboratory setting, studying immunology, molecular biology, hematology and/or stem cell biology.
• Experience with the use of advanced flow cytometry equipment (including LSRII, Sony XDP Sorter, Cytek Aurora and FACSAria II) for analysis and sorting of cells, and development of multicolor antibody staining panels.
• Experience in mouse handling, husbandry and dissection.
• Experience in experimental hematology and molecular biology assays and techniques, including HSC isolation and analysis, and high-throughput sequencing.
• Experience in bioinformatic analysis of large datasets with proficiency in R or Python
• Candidates that have successfully obtained competitive, extramural funding during their doctoral studies are preferred.

Knowledge, Skills and Abilities:

• Excellent written and verbal communication skills.
• Ability to work independently and as a team member within a research environment.
• Ability to work efficiently and effectively with computer software including Microsoft Office.
• Skilled with the use of aseptic mammalian cell culture techniques.
• Skilled with common laboratory techniques and equipment consistent with PhD-level graduate training.
• Ability to commit to an independent scientific career in stem cell biology, immunology, or a related field, with a proven high degree of independence and self-motivation to achieve these ends.
• Ability to work a flexible schedule based on the needs of the project.

How to Apply:

For full consideration, please submit the…