Post-Doctoral Fellow

Post-Doctoral Fellow

A postdoctoral associate position is available immediately in the laboratory of Elan Eisenmesser at the University of Colorado School of Medicine (Anschutz Medical Campus). The Eisenmesser laboratory is located in a highly collaborative structural biology environment with access to:
Bruker 600 MHz and 900 MHz NMR spectrometers with cryoprobes, an on-site 200 kV Talos Arctica cryo-EM facility, proteomics and metabolomics mass spectrometry cores, and a comprehensive biophysics core facility. All major instrumentation is located in the same building.

Our group uses an integrative structural biology approach to understand how macromolecular structure and dynamics control function in systems relevant to infectious disease. We combine solution NMR spectroscopy (structure, dynamics), cryo-EM of large macromolecular assemblies, and biochemistry and molecular biology. Current projects include bacterial proteases that manipulate host pathways, with emphasis on conformational exchange and its role in enzyme mechanisms, and macromolecular assemblies involved in microbial metabolism with a particular focus on protein-protein regulatory mechanisms.

The successful candidate will apply advanced NMR methods and develop cryo-EM expertise to study structure–dynamics–function relationships in these systems.

Work location:

Onsite – this role is expected to work onsite and is located in Aurora, CO.

The University of Colorado offers a comprehensive benefits package. To see what benefits are available for Post-Doctoral Fellows, please visit:
Payroll & Benefits Orientation for Post-Doctoral Fellows | University of Colorado (cu.edu) and Post-Doctoral Benefits Guide. There are many additional perks & programs with the CU Advantage.

Minimum qualifications:

Applicants must meet minimum qualifications at the time of hire. A Ph.D. in biochemistry, structural biology, biophysics, or a related field. Strong experience in biomolecular NMR. Experience with cryo-EM is welcome but not required. The position is ideal for candidates interested in expanding from NMR into integrative structural biology.

Knowledge, skills and abilities:

Strong written and verbal communication skills, including the ability to contribute to manuscripts and presentations. Ability to lead and troubleshoot research projects. Experience analyzing complex experimental or computational datasets and synthesizing results into clear conclusions. Ability to mentor junior researchers and collaborate effectively within a multidisciplinary research environment. Ability to manage multiple projects, meet research deadlines, and contribute positively to a rigorous and inclusive lab culture.

Expertise in protein expression and purification.

For full consideration, please submit the following document(s): A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position, curriculum vitae / resume, and five professional references including name, address, phone number (mobile number if appropriate), and email address. Applications are accepted electronically ONLY .edu/cu-careers. Questions should be directed to:
Elan Eisenmesser, Elan.

Eisenmesser.