Post-Doctoral Fellow

Post-Doctoral Fellow

The Department of Pediatrics at the University of Colorado Anschutz is looking for a post-doctoral fellow to join our lab. The fellow will be responsible for driving an independent project studying neurodegeneration using human cells and tissues. Model systems and techniques include using post-mortem brain tissue and human cell lines, as well as long read and single cell sequencing. Experience and/or comfort with these paradigms are a critical component of this role.

The goal of the research project broadly is to better understand essential mechanisms underlying the disorder Fragile X-associated tremor/ataxia syndrome, a neurodegenerative disorder associated with cognitive decline, psychiatric co-morbidities, and tremor and ataxia. Our lab affords a collaborative mind-set and opportunities for professional development and growth for those with a variety of career aspirations. Former and current lab members have been highly successful in publishing, obtaining fellowships, and pursuing long-term professional goals.

Key Responsibilities:

• Developing testable hypotheses and conducting molecular biology experiments and analyses including but not limited to high molecular weight DNA extraction & sequencing, RNA expression/studies, single-cell
  -omics experiments, in situ studies, and cell culture work
• Analyzing sequencing data including long read DNA sequencing, bulk RNA-seq, and single-nucleus RNA/ATAC using R, python, command line interface and high-performance computing clusters
• Thorough documentation and communication of experiments and findings with lab notebook, appropriate version control
• Presentations expected at lab meetings, and at regional and national conferences
• Supervision of more junior laboratory members

Work Location:

Onsite – this role is expected to work onsite and is located in Aurora, CO.

Qualifications:

Minimum Qualifications:

• PhD in Neuroscience, Human Genetics, Developmental Neurobiology, Molecular Biology or related field
• One (1) year experience working with post-mortem brain tissue or equivalent (other primary human tissue/cell work, and/or using BSL2 or greater precautions)
• One (1) year experience with hIPSC-derived cell culture or equivalent (human lines such as fibroblasts, lymphoblasts) and cell culture sterile technique

Condition of Employment:

• Applicants must be legally authorized to work in the United States without requiring sponsorship.
• We are unable to provide work visa sponsorship or employment authorization for this position now or in the future.
• Must successfully pass a drug test through Children's Hospital Colorado
• Must be willing and able to pass a national criminal background check

Preferred Qualifications:

• One (1) year experience with R, python, or equivalent analysis of sequencing data such as long-read or single-cell RNA and DNA methods
• Two to five (2-5) years of experience working with post-mortem brain tissue or equivalent (other primary human tissue/cell work, and/or using BSL2 or greater precautions)
• Two to five (2-5) years of experience with hIPSC-derived cell culture or equivalent (human lines such as fibroblasts, lymphoblasts) and cell culture sterile technique

Knowledge, Skills and Abilities:

• Working knowledge of common molecular biology techniques such as qPCR, IHC, protein extraction and assessment, sterile cell culture, cloning, etc
• Ability to clearly document experiments and analyses
• Ability to work collaboratively & professionally
• Ability to independently trouble-shoot experiments and learn new techniques
• Demonstrated productivity with respect to: prior publications competitive prior and/or current funding/travel awards/fellowships oral presentation at regional and national levels

How to Apply:

For full consideration, please submit the following document(s):

• A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position
• Curriculum vitae / Resume
• Five professional references including name, address, phone number (mobile number if appropriate), and email address

Applications are accepted electronically ONLY .edu/cu-careers. Questions should be directed to:
Caroline.dias Screening of…