Laboratory Science Professional Entry – Principal

University of Colorado Anschutz Department:
Biochemistry & Molecular Genetics

Job Title:

Laboratory Science Professional (Open Rank: Entry –Principal)

Position #:  – Requisition #: 39551

The Cui Lab () is seeking a Research Services Professional at the Entry, Intermediate, Senior, or Principal level to join our newly established research program. Our lab investigates the structural logic of mTORC1 signaling
, metabolic regulation
, and membrane remodeling
. We use an integrative approach, combining high‑resolution cryo‑electron microscopy (cryo‑EM), biochemistry, and molecular biology, to understand how protein complexes and small GTPases function on the lysosomal surface.

The successful candidate will be a founding member of the lab, providing critical technical and administrative support. Primary responsibilities include performing molecular biology and biochemistry experiments, maintaining mammalian cell cultures, and managing essential lab operations such as inventory, ordering, and safety compliance. This role offers the opportunity to contribute to cutting‑edge structural biology research while helping to establish the foundational workflows of a new scientific team.

• Experimental Execution: Conduct molecular biology workflows, including cloning, mutagenesis, and plasmid preparation. Perform protein expression and purification using insect or mammalian systems.
• Cell Culture Management: Maintain and manipulate mammalian cell lines, ensuring consistent quality for biochemical and structural studies.
• Structural Biology Support: Assist in the preparation of samples for cryo‑EM and cryo‑ET, and support the maintenance of specialized laboratory equipment.
• Lab Operations: Coordinate daily lab activities, including ordering supplies, managing chemical and biological inventories, and maintaining shared databases (e.g., plasmid and cell line registries).
• Safety & Compliance: Serve as the primary point of contact for Environmental Health and Safety (EHS) to ensure the lab remains in full regulatory compliance.
• Collaboration: Work closely with the PI and postdoctoral fellows to design and optimize experimental protocols.

Onsite – this role is expected to work onsite and is located in Aurora, CO.

Our department conducts research across a wide biological scale for fundamental scientific understanding with applications to many disease contexts. The overarching goal is to reach a level of molecular insight that helps develop therapeutic approaches to disease. As biochemists and molecular geneticists, we are amid an unprecedented time of discovery – our conception of the molecular biology of cells is going from the equivalent of grainy black‑and‑white to high‑resolution technicolor.

From deciphering the choreography of transcription complexes, chromosomes, and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell's machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefront of their fields both conceptually and technologically.

We have amazing benefits and offer exceptional amounts of holiday, vacation and sick leave! The University of Colorado offers an excellent benefits package including:

• Medical:
  Multiple plan options
• Dental:
  Multiple plan options
• Additional Insurance:
  Disability, Life, Vision
• Retirement 401(a) Plan:
  Employer contributes 10% of your gross pay
• Paid Time Off:
  Accruals over the year
• Vacation Days: 22/year (maximum accrual 352 hours)
• Sick Days: 15/year (unlimited maximum accrual)
• Holiday Days: 10/year
• Tuition Benefit:
  Employees have access to this benefit on all CU campuses
• ECO Pass:
  Reduced rate RTD Bus and light rail service

There are many additional perks & programs with the CU Advantage.

• Bachelor's degree in biology, molecular biology, chemistry, genetics or related field

• Bachelor's degree in biology, molecular biology, chemistry, genetics or related field
• One (1) year professional level research…