Cohen Lab- Postdoctoral Fellow

University of Colorado Anschutz
Department:
Department of Surgery- GITES
Job Title:
Cohen Lab
- Postdoctoral Fellow
Position #: – Requisition#:40643

NIH/DoD/DARPA-funded lab studying trauma-induced coagulopathy andthromboinflammation. Focus on protein C system biology, endothelialdysfunction, and novel therapeutics. Translational approach spanshuman biorepository, mouse models, and multiomics.

The Cohen Lab at CU Anschutz (NIH/DoD/DARPA-funded) seeks apostdoctoral fellow supported by the NIH T32 Critical Injury and Illness Training Program. The R01-funded project centers on theprotein C pathway as the mechanistic bridge between trauma-inducedcoagulopathy (TIC) and thromboinflammation. Work uses human traumabiorepository samples, validated mouse models of hemorrhagic shock,a 3D endothelial flow model, and high-throughput proteomics,metabolomics, and lipidomics. Projects include therapeuticmodulation of APC activity via nanobodies and engineered variants,endothelial barrier and calcium signaling assays, and multiomicphenotyping of post-injury states.

Candidates should hold a PhD inbiochemistry, molecular biology, cell biology, or bioengineeringwith experience in endothelial cell models, microfluidic/flowsystems, rodent models, and/or multiomics. Strong interest intranslational research at the intersection of coagulation,inflammation, and therapeutics is required.

The fellow will contribute to ongoing R01-funded aims focused on:(1) mechanistic characterization of protein C pathway activation intrauma-induced coagulopathy using clinical patient samples and exvivo mixing studies with APC-selective nanobodies and engineeredsuperFVa; (2) endothelial biology of thromboinflammation includingbarrier function, calcium signaling, and mitochondrial metabolicdysfunction studied in a novel 3D flow model and validated mousemodels of hemorrhagic shock; and (3) multiomic (proteomic,metabolomic, lipidomic) endotyping of post-injury phenotypes andtrajectories using a biorepository of >10,000 samples fromseverely injured patients.

The fellow will be co-mentored by Dr. Mitchell J. Cohen MD FACS(trauma surgeon-scientist, Professor of Surgery, Bruce Rockwell Chair) and a multidisciplinary team including experts incoagulation biology, proteomics/metabolomics, thrombosis modeling,and bioengineering. The NIH T32 Critical Injury and Illness Training Program provides structured training in grant writing,scientific communication, and career development. The fellow willhave access to state-of-the-art core facilities at CU Anschutzincluding mass spectrometry, flow cytometry, high-resolutionmicroscopy, and a dedicated Level 1 Trauma Centerbiorepository.

Onsite – this role is expected to work onsite and is located in Aurora, CO.

The Department of Surgery's leading-edge research programs focus on the search for the next cure, newest innovations, and breakthroughclinical trials. Our faculty, researchers, and students arerelentless in their pursuit of discoveries that will transform thefuture of surgery.

The University of Colorado Anschutz Medical Campus is acomprehensive urban research university serving more than 28,000students in metropolitan Denver and online. With our solid academicreputation, award-winning faculty and renowned researchers, weoffer 119 highly rated degree programs through 13 schools and colleges. The University of Colorado Anschutz Medical Campus iswell known for its distinctive and highly productive researchprograms, its world-class health facilities at the Anschutz Medical Campus, and its well-established partnerships in business,industry, and government.

These campuses currently have over $757million in research awards each year.

The University of Colorado offers a comprehensive benefits package. To see what benefits are available for Post-Doctoral Fellows,please visit:

• Payroll & Benefits Orientation for Post-Doctoral Fellows |University of Colorado (cu.edu)
• benefits guide cover-post-doc-2024 (cu.edu)

Applicants must meet minimum qualifications at the time of hire.

• PhD…