Post-Doctoral Fellow

University of Colorado Anschutz Medical Campus

Department of Pediatrics | Section of Genetics & Metabolism

Job Title:

Postdoctoral Fellow

Position #:  

- Requisition #:40462

Job Summary:

The Department of Pediatrics at the University of Colorado Anschutz is looking for a post-doctoral fellow to join our lab (diaslab.org). The fellow will be responsible for driving an independent project studying neurodegeneration using human cells and tissues. Model systems and techniques include using post-mortem brain tissue and human cell lines, as well as long read and single cell sequencing. Experience and/or comfort with these paradigms are a critical component of this role.

The goal of the research project broadly is to better understand essential mechanisms underlying the disorder Fragile X-associated tremor/ataxia syndrome, a neurodegenerative disorder associated with cognitive decline, psychiatric co-morbidities, and tremor and ataxia. Our lab affords a collaborative mind-set and opportunities for professional development and growth for those with a variety of career aspirations. Former and current lab members have been highly successful in publishing, obtaining fellowships, and pursuing long-term professional goals.

Key Responsibilities:

* Developing testable hypotheses and conducting molecular biology experiments and analyses including but not limited to high molecular weight DNA extraction & sequencing, RNA expression/studies, single-cell
-omics experiments, in situ studies, and cell culture work

* Analyzing sequencing data including long read DNA sequencing, bulk RNA-seq, and single-nucleus RNA/ATAC using R, python, command line interface and high-performance computing clusters

* Thorough documentation and communication of experiments and findings with lab notebook, appropriate version control

* Presentations expected at lab meetings, and at regional and national conferences

* Supervision of more junior laboratory members

Work Location:

Onsite - this role is expected to work onsite and is located in Aurora, CO.

Why Join Us:

With an abundance of sunshine and mountains nearby, the Colorado Front Range is the place to be! The University of Colorado Anschutz Medical Campus ranks among the top 20 medical centers in the country. CU Anschutz has top ranked clinical programs in family medicine and pediatrics, and the basic science and applied health research programs attract more NIH funding than any other university in Colorado.

CU-Anschutz is home to the University of Colorado Hospital, The Children's Hospital of Colorado, and the University of Colorado Schools of Medicine, Nursing, Dentistry, Pharmacy and Pharmaceutical Sciences, and Public Health, providing access to an array of possibilities to improve lives across a spectrum of ages and disease states.

The University of Colorado offers a comprehensive benefits package. To see what benefits are available for Post-Doctoral Fellows, please visit:

Payroll & Benefits Orientation for Post-Doctoral Fellows | University of Colorado (cu.edu)

benefits guide cover-post-doc-2024 (cu.edu)

Qualifications:

Minimum Qualifications:

Applicants must meet minimum qualifications at the time of hire.

● PhD in Neuroscience, Human Genetics, Developmental Neurobiology, Molecular Biology or related field

● One (1) year experience working with post-mortem brain tissue or equivalent (other primary human tissue/cell work, and/or using BSL2 or greater precautions)

● One (1) year experience with hIPSC-derived cell culture or equivalent (human lines such as fibroblasts, lymphoblasts) and cell culture sterile technique

Condition of Employment:

* Applicants must be legally authorized to work in the United States without requiring sponsorship. We are unable to provide work visa sponsorship or employment authorization for this position now or in the future.

* Must successfully pass a drug test through Children's Hospital Colorado

* Must be willing and able to pass a national criminal background check

* For questions regarding Children's Hospital drug testing requirements, please contact Children's Human Resources at . Some positions may require testing if access to Children's Hospital or their systems is…