Post-Doctoral Fellow

University of Colorado Anschutz

Department: SOM, Biochemistry & Molecular Genetics

Job Title:

Post-Doctoral Fellow (Term-limited, 1 year)

Position #:

- Requisition #:39257

Job Summary:

The laboratory of Dr. Olivia Rissland seeks to hire a Post-Doctoral Fellow for a one-year appointment to work on leading edge questions in RNA biology pursued as part of our research program outlined below. Our lab is in the Department of Biochemistry and Molecular Genetics and part of the RNA Bioscience Initiative at the University of Colorado School of Medicine. Our lab studies how co-translational processes regulate gene expression and is newly focused on leveraging these insights to create novel molecular tools.

One long-term goal of our research program is to understand the molecular mechanism of 2A peptides. These short 20-22 amino acid sequences enable a unique co-translational event - the skipping of a peptide bond - and thus the production of multiple, separate peptides from one coding region. The postdoctoral fellow will investigate the molecular mechanism, using a suite of tools including cryo-electron microscopy.

The fellow will also initiate a new project to build a "second-generation," tunable 2A peptide, which will involve high-throughput microscopy screening and massively parallel reporter assays. Ideal candidates will have expertise in structural biology. Candidates will be expected to plan and execute independent work, write and submit fellowship applications (if applicable), assist in the writing and publication of experimental results, and contribute positively towards the atmosphere and culture of the lab.

Key Responsibilities:

* Lead an independent research project to define the molecular and structural mechanisms of 2A peptide function and develop novel molecular tools based on these insights.

* Design and execute experiments using structural biology approaches (required), including cryo-EM, in combination with mammalian cell culture, RNA biochemistry, nucleic acid purification and sequencing, genome engineering, computational biology, and molecular genetics.

* Analyze and interpret complex structural and biochemical datasets to advance the lab's research objectives.

* Develop new technical expertise as needed, including gaining proficiency in RNA biology and related methodologies.

* Contribute to the preparation of manuscripts, grant applications (internal and external), and scientific presentations for meetings and conferences.

* Mentor and train junior scientists in experimental design, data analysis, and professional scientific development.

Work Location:

Onsite - this role is expected to work onsite and is located in Aurora, CO.

Why Join Us:

Our department conducts research across a wide biological scale for fundamental scientific understanding with applications to many disease contexts. The overarching goal is to reach a level of molecular insight that helps develop therapeutic approaches to disease.

As biochemists and molecular geneticists, we are amid an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes, and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell's machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

Why work for the University?

The University of Colorado offers a comprehensive benefits package. To see what benefits are available for Post-Doctoral Fellows, please visit:

* Payroll & Benefits Orientation for Post-Doctoral Fellows | University of Colorado (cu.edu)

* Post-Doctoral Benefits Guide

There are many additional perks & programs with the CU Advantage.

Qualifications:

Minimum Qualifications:

Applicants must meet minimum qualifications at the time of hire.

* A Ph.D. in structural biology or a related field

* Strong record of productivity as evidenced by peer-reviewed publications in…