Postdoctoral Associate

About The Job

The overall objective of the lab is to understand the mechanisms modulating resistance to therapy and use the knowledge gained from these studies to develop novel therapies for glioblastoma. To this end, we utilize genome-wide screening to identify molecular modifiers of therapy sensitivity, especially to temozolomide (TMZ). We have already identified over six hundred potential druggable modulators of TMZ resistance. The post-doctoral fellow will perform secondary validation to identify the best candidates and use biochemical and pharmacological strategies to evaluate the mechanisms by which these candidates sensitize TMZ in glioblastoma cells in vitro and in vivo.

The employer retains the right to change or assign other duties to this position.

The overall objective of the lab is to understand the mechanisms modulating resistance to therapy and use the knowledge gained from these studies to develop novel therapies for glioblastoma. To this end, we utilize genome-wide screening to identify molecular modifiers of therapy sensitivity, especially to temozolomide (TMZ). We have already identified over six hundred potential druggable modulators of TMZ resistance. The post-doctoral fellow will perform secondary validation to identify the best candidates and use biochemical and pharmacological strategies to evaluate the mechanisms by which these candidates sensitize TMZ in glioblastoma cells in vitro and in vivo.

The employer retains the right to change or assign other duties to this position.

• Conduct in vitro and in vivo studies to assess the efficacy of novel therapeutic targets, both alone and in combination with temozolomide and/or radiation.
• Investigate underlying mechanisms of action using a range of biochemical and pharmacological.

• Use shRNA/CRISPR gene-targeting approaches to validate novel targets identified through secondary, custom-designed siRNA library screening.

• Mentor research technologists, students, and/or interns.
• Prepare and contribute to manuscripts for publication.
• Participate in local and national scientific meetings.

The Research and Innovation Office (RIO) and The Hormel Institute endorses a "work with flexibility" approach that offers a welcoming and flexible work environment where everyone is inspired to do their best. Work location options include working fully remote, partially remote, or entirely in the office and are based on the work of the position. Some on-site work may be necessary for certain positions, even those designated as fully remote.

Because we are a land-grant institution that serves the state, the University will continue to- in most cases- expect employees to live in Minnesota.

This position has been designated as eligible for Flexible Work Profile One.

Flexible Work Profile One, Office/Lab-Based - is expected to work primarily on-site in the office/lab. Only occasionally and inconsistently working remotely. Your office will be located at The Hormel Institute in Austin, Minnesota. The Hormel Institute management retains the right to modify flexible work arrangement agreements on a temporary or permanent basis for any reason at any time.