Medical Director

XBiotech USA Inc. is fully integrated biopharmaceutical company developing a diversified portfolio of biologics across multiple therapeutic areas. We are advancing several assets from early clinical development through commercialization, with a mission to transform patient outcomes through groundbreaking science. From pre-clinical models to clinical trial execution, from discovery to manufacturing, all activities are under one roof. XBiotech is focused on developing antibody therapeutics targeting the major medical needs of inflammatory diseases, cancer and infectious diseases.

XBiotech’s drug Research & Development center is headquartered in Austin, Texas. Our Austin facility incorporates all critical operations including discovery, research and development, drug testing, product formulation as well as clinical-regulatory affairs. Our excellent facilities allow us to effectively implement and fully develop any program we adopt. We are working to change the future of medicine.

We are seeking a Medical Director with proven early-stage pharmaceutical/biotech experience to provide medical leadership across our multi-therapeutic area biologics portfolio. This role requires exceptional generalist capabilities combined with collaborative leadership skills; someone who can effectively leverage external therapeutic area experts, key opinion leaders, and clinical consultants to ensure both scientific rigor and operational agility. You will serve as a trusted medical voice internally and externally, seamlessly bridging clinical development and medical affairs as we advance our pipeline.

• Provide medical oversight and strategic input for clinical trials across multiple therapeutic areas including oncology, rheumatology and infectious diseases
• Collaborate with cross-functional teams to design clinical development plans and study protocols for diverse indications
• Serve as medical monitor for clinical trials, ensuring patient safety and data integrity across programs
• Coordinate with therapeutic area consultants and advisors to ensure clinical and scientific expertise for each program
• Review and interpret clinical data across different therapeutic areas to guide development decisions and regulatory strategies
• Contribute to regulatory submissions including INDs, and responses to health authority queries

• Build and manage a network of therapeutic area experts, clinical consultants, and scientific advisors
• Establish relationships with key opinion leaders (KOLs) across multiple therapeutic areas
• Coordinate scientific advisory boards and leverage external expertise for study design and data interpretation
• Identify and engage consultants for specific therapeutic area needs as programs advance
• Synthesize input from multiple experts to make informed medical and strategic decisions

• Build and lead medical affairs capabilities as the company scales
• Create scientific communication materials including publications, presentations, and medical education content
• Establish relationships with key opinion leaders (KOLs) and scientific advisory boards
• Oversee investigator-initiated studies

• Partner with regulatory affairs to ensure scientific rigor in submissions across therapeutic areas
• Work closely with clinical operations to ensure trial execution aligns with medical objectives
• Prioritize resources and balance competing demands across multiple programs

• Represent the company at scientific conferences and medical meetings across relevant therapeutic areas
• Present clinical data to investigators, healthcare professionals, and scientific audiences
• Engage with patient advocacy groups to understand unmet medical needs
• Participate in scientific discussions with regulators

• MD, or equivalent medical degree with active medical license
• Minimum 5-7 years of clinical medicine and/or pharmaceutical industry experience in an early stage pharma/biotech company
• Strong understanding of biologics development, including regulatory pathways and CMC considerations
• Demonstrated experience in clinical trial design, execution, and medical monitoring across multiple programs
• Proven ability to work effectively with external consultants and leverage therapeutic area expertise
• Experience coordinating scientific advisory boards and managing expert networks
• Deep knowledge of drug development lifecycle from IND through commercialization
• Experience with FDA and international regulatory agencies
• Excellent scientific writing and communication skills with ability to synthesize complex information
• Strong organizational skills and ability to prioritize across multiple concurrent projects
• Proven ability to work effectively in a fast-paced, resource-constrained entrepreneurial environment
• Comfort with ambiguity and ability to make sound decisions with incomplete…