Biologist (Genomics) (50865

Job Details Level: Experienced

Job Location:

National Institutes of Health (NIH) - Baltimore Campus - Baltimore, MD 21224 Position Type:
Full Time Education Level: Masters Degree Salary Range: $70,000.00 - $ Salary/year Travel Percentage:
None Job Shift: Day Job Category:
Public Health Position Objective:
The National Institutes of Health requires contractor support for laboratory and computational analysis of genomic and epigenomic data. The work supports ongoing research involving genotyping, long-range sequencing, and DNA methylation profiling at the National Institute on Aging (NIA) within the National Institutes of Health (NIH).

• Evaluate:
  Read quality, coverage, and depth and Sample integrity and contamination
• Flag anomalies and provide preliminary interpretation.
• Perform DNA extraction from blood, tissue, or cultured cells using established protocols. 1
• Conduct genotyping assays (e.g., SNP arrays, PCR-based methods 2
• Support long-range sequencing workflows (e.g., library prep and sequencing using long-read platforms such as Pac Bio or Oxford Nanopore). 3
• Perform DNA methylation assays (e.g., bisulfite conversion, array-based or sequencing-based methods).
• Execute established QC pipelines for sequencing and genotyping data.
• Compile and document QC metrics in standardized formats.
• Modify existing scripts and pipelines to support project needs.
• Perform data analysis using: R (statistical analysis and visualization) and Scripting (Python, Bash, or equivalent)
• Conduct:
  Variant calling and basic annotation and DNA methylation data processing and analysis and Data integration across datasets when directed
• Maintain accurate laboratory notebooks and electronic records.
• Identify routine technical issues and implement standard troubleshooting steps.
• Prepare:
  Summary tables and figures and Written summaries of methods and results
• Present findings in internal meetings to NIH staff
• Contribute to draft reports, manuscripts, or project updates.
• Sample Processing Logs DNA extraction records and yields
• Genotyping/Sequencing Outputs Raw and processed data files
• QC Reports Standardized quality metrics and summaries
• Analysis Outputs Variant and methylation results, visualizations
• Scripts and Code Documented R/Python/Bash scripts
• Monthly Summary of work performed and findings
• Presentation Materials Slides or briefings for NIH staff

• Masters Degree in Biology or similar field of study
• At least 2 years of experience
• Proficiency in R and at least one scripting language
• Experience with QC and data visualization
• Familiarity with genomic data formats (FASTQ, BAM, VCF)

• Strong communication skills, both oral and written.
• Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects.

* This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by law.

This position is contingent upon contract award.