Sr. Director, Clinical Scientist, Oncology

Tyra Biosciences, Inc
. (Nasdaq: TYRA) is a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in FGFR biology. The Company's in-house precision medicine platform, SNÅP, enables the rapid and precise refinement of structural drug design through iterative molecular SNÅPshots that help predict genetic alterations most likely to cause acquired resistance to existing therapies. TYRA's initial focus is on applying its accelerated small molecule drug discovery engine to develop therapies in targeted oncology and genetically defined conditions.

TYRA is based in Carlsbad, CA.

Tyra Biosciences, Inc. is seeking a highly motivated Sr. Director, Clinical Scientist to make impactful contributions to oncology drug discovery projects targeting disease areas with high unmet medical need. The successful candidate will be highly organized, self‑motivated, and thrive in a dynamic, cross‑functional start‑up environment.

This position requires broad knowledge and experience across the clinical development spectrum, specifically late‑stage development. This individual will contribute to the development, planning, and execution of Tyra’s clinical research strategy. A clinical scientist provides support for programs as assigned by compound, phase, or therapeutic area.

• Must have experience working in all phases of clinical research (Phases 1‑3); phase 3 experience must be large, controlled, global studies
• Work cross‑functionally to contribute to the design and development of clinical research protocols for assigned clinical research studies
• Maintain a thorough understanding of the protocol, including the history of all previous versions
• Conduct and collaborate on all data review/generation activities that include but are not limited to ongoing and final clinical data review, query resolution to ensure consistent, quality data
• Ability to access/review raw data in the clinical study database and generate GCP appropriate queries as needed.
• Contribute to and collaborate with Data Management on the development of case report forms/electronic data capture (EDC), including weighing in on edit checks, tolerance limits and other aspects related to developing and updating a study database.
• Contribute to and collaborate with Biostatics/Programming on the development of/review of tables, listings and figures (TLFs) for assigned clinical studies. The TLFs may be outputs for different needs (i.e., DSUR/IB, abstracts). Additional collaboration with other members of Tyra may be necessary to determine the proper output requirements.
• Identify clinical data trends; provide trends and escalate questions to study physician.
• Attend study related/compound related meetings to understand study/compound strategy; contribute as needed to the program strategy, clinical development plans, and corporate materials, in collaboration with the program’s Asset Lead
• Lead the development of the informed consent forms; also responsible for any updates to the risk section following DSUR/IB updates
• Contribute to the development and review of Investigator Brochures, annual reports and other Health Authority submissions (i.e., Request for Information).
• Attend and present clinical updates on assigned compounds/programs as requested to internal personnel (i.e., senior management) or external (i.e., Steering Committee).
• Develop relationships with appropriate consultants and External Experts to gain and apply insights on protocol design and compound strategy
• Contribute to the development of abstracts, posters, oral presentations, and manuscripts for external publications
• Contribute to or lead process improvement initiatives
• Maintain updated knowledge of competitive landscape with regard to assets similar to Tyra’s compounds, as well as evolving standards of care for indications of interest
• Collaborate and liaise with internal cross‑functional team members
• Meet with lead PIs/KOLs at conferences
• Consult when/if asked by Clinical Operations on any aspect of the study and/or program
• Advanced Degree in scientific/life‑sciences field with a Master’s, PharmD, or Ph.D.,…