Associate Scientist, In vivo Pharmacology

About Stoke

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study.

In 2025, Stoke entered a strategic collaboration with Biogen to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico;
Biogen receives exclusive rights to commercialize the drug worldwide.

STK-002 is Stoke’s proprietary antisense oligonucleotide in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has received orphan drug designation from the FDA. A Phase 1 study (OSPREY) of STK-002 in individuals with ADOA is underway. The company is also conducting early research on Syngap1, a severe and rare neuro‑developmental disorder, in collaboration with Acadia Pharmaceuticals.

The initial focus is on diseases of the central nervous system and the eye caused by loss of approximately 50 % of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organ systems, supporting broad potential for the company’s proprietary approach.

Stoke is seeking an enthusiastic and highly motivated Associate Scientist to join the In Vivo Pharmacology Department. This position offers the opportunity to learn new techniques and concepts, be creative, and grow with a dynamically expanding company.

• Design and execute routine studies to investigate the PK/PD and efficacy of drug candidates.
• Perform routine to intermediate handling procedures and injections (IV, SC, IP, ICV), monitor animal health, and collect tissues in mice.
• Perform moderately complex behavioral experiments in animal models.
• Support the implementation of new animal models.
• Demonstrate technical proficiency to investigate, identify, develop, optimize, and troubleshoot new methods, techniques, or instrumentation to address critical project needs.
• Read and understand scientific literature.
• Analyze data, author technical reports, and document experiments in an electronic notebook.
• Participate in and present at project team and departmental meetings.
• Maintain laboratory organization, including equipment upkeep, and ensure compliance with safety protocols.
• Collaborate across functional areas.
• Additional responsibilities as assigned.

• BS with 7+ years post‑graduate experience or MS with 4+ years of experience working in a biotechnology or pharmaceutical company or contract research organization.
• Experience with molecular biology assays such as qPCR, ELISA, MSD, BCA, and Western blot (or JESS) in tissue matrix.
• Experience with ISH/IHC assays and analysis.
• Proficiency with animal handling procedures and injections (IV, SC, IP, and ICV).
• Experience working with animal disease models.
• Experience in neuroscience.
• Experience with animal behavioral assays a plus.
• Strong organizational skills and attention to detail.
• Strong verbal and written communication skills.
• Creative thinking and the ability to work well in a team environment.

Stoke is located in Bedford, MA, and will move to a new location in Waltham, MA by the end of 2026. This is an in‑person position based in Bedford, MA.

This position will require travel.

At Stoke Therapeutics, we offer a comprehensive, competitive, and thoughtfully designed total rewards program. The anticipated salary range for this role is $110,000 – $131,000. The final offer will be determined by role scope, experience, qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes…