Senior Research Associate, Formulation

About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study.

Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study.

Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit

We are seeking a highly motivated and detail-oriented Senior Research Associate to join our Early Development team focused on oligonucleotide-based therapeutics. This role offers a unique opportunity to contribute to the design and development of innovative drug formulations at the preclinical and early clinical stages. You’ll work closely with cross-functional teams to support formulation screening, in vitro and in vivo formulation preparation, and process development for novel oligonucleotide candidates.

This position will report into Senior Principal Scientist, formulation lead.

• Support the design and execution of formulation studies for oligonucleotide drug products
• Perform laboratory experiments in a safe and efficient manner and record research findings in ELN
• Collaborate with analytical, process development, and manufacturing teams to ensure seamless tech transfer
• Support analytical testing and interpretation of data related to physical and chemical stability
• Contribute to the preparation of technical reports, presentations, and regulatory documentation
• Stay current with scientific literature and industry trends in oligonucleotide formulation and delivery
• Additional tasks as assigned

• B.S. with 4 years of experience or M.S. with 2 years of experience in Chemistry or Organic Chemistry
• Prior industry experience in oligonucleotide formulation and scale-up is desired
• Sound knowledge of analytical chemistry and basic nucleic acid chemistry is preferred
• Experience with UPLC, LCMS and formulation characterization instrument is desired
• Hands-on experience with lab techniques such as pH adjustment, UV spectroscopy, endotoxin and physical property measurement; hand-on experience with HPLC/UPLC is a plus
• Strong organizational skills and attention to detail
• Excellent communication and teamwork abilities

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a lab-based position currently based in Bedford and will later be based in Waltham.

This position will require approximately 5% travel.

The anticipated salary range for this role is $99,000 - $108,000.

In addition to base salary, Stoke offers…