Clinical Research, Senior Principal Scientist; Director), Oncology

Lantheus (NASDAQ: LNTH) is the leading radiopharmaceutical-focused company, delivering life-changing science to enable clinicians to Find, Fight and Follow disease to deliver better patient outcomes. Headquartered in Massachusetts with offices in New Jersey, Canada, Germany, Sweden, Switzerland and United Kingdom, Lantheus has been providing radiopharmaceutical solutions for nearly 70 years.

Today, we’re expanding our portfolio and pipeline across oncology, neurology and cardiology. Through recent acquisitions, along with strategic partnerships across the life sciences ecosystem, we are accelerating our efforts to advance precision medicine and improve patient outcomes around the world.

At Lantheus we are purpose-driven, and every employee plays a vital role in our success. We’re dedicated to cultivating a high-growth, forward-thinking culture where innovation thrives and diverse perspectives drive meaningful progress.

Join us and be part of a company where your contributions make a real impact, because we know someone’s health is in our hands.

The Clinical Research, Senior Principal Scientist, Oncology is a senior, director-level individual contributor and recognized scientific expert who provides strategic and scientific leadership for oncology clinical development programs. The role shapes clinical research strategy and leads the scientific design, execution, interpretation and communication of company-sponsored clinical research, with particular emphasis on diagnostic imaging, radiopharmaceuticals and molecular imaging.

Working in close partnership with the Executive Director, Head of Clinical Development, Oncology, the position translates complex clinical, scientific and competitive information into clear recommendations that support asset, indication and portfolio decisions. The incumbent operates with a high degree of independence, influences cross-functional teams without direct authority and represents Clinical Development in governance, regulatory and external scientific forums.

This position is based in Bedford, MA and requires a presence on-site two to three days per week. It is open to applicants authorized to work for any employer within the United States.

• Serve as the scientific lead for assigned oncology diagnostic development programs and provide expert guidance across Phase I-IV clinical studies, from concept development through study close-out and lifecycle management.
• Develop and refine clinical development strategies, clinical research plans, target product profiles, study concepts, protocols, endpoints and evidence-generation approaches for oncology indications.
• Lead the scientific design and interpretation of company-sponsored clinical research in oncology, including clinical study documents, imaging endpoints, biomarker strategies, patient-selection approaches and diagnostic performance considerations.
• Translate emerging clinical findings into clear, evidence-based strategic recommendations aligned with asset and portfolio objectives; identify key uncertainties, development risks and decision points.
• Provide scientific leadership to cross-functional teams spanning Clinical Operations, Imaging Sciences and Operations, Biostatistics, Regulatory Affairs, Medical Affairs, Pharmacovigilance, CMC, Translational Sciences and external partners.
• Guide scientific and clinical aspects of study execution, including protocol interpretation, data review, analysis planning, issue resolution and preparation for governance decisions.
• Contribute scientific content to regulatory strategies, briefing documents, submissions and responses to health authority questions; support interactions with FDA, EMA and other applicable authorities.
• Maintain awareness of internal and external scientific, clinical, competitive and regulatory developments that could affect oncology development plans and proactively recommend appropriate action.
• Build and sustain relationships with investigators, key opinion leaders, cooperative groups, academic collaborators, CROs and other external experts.
• Lead or contribute to scientific communication and publication plans, including abstracts, manuscripts, congress presentations, data summaries and symposia.
• Mentor and provide scientific guidance to clinical scientists and project team members; promote rigorous scientific thinking, high-quality decision-making and consistent execution.
• Implement applicable requirements of the Lantheus quality assurance system and ensure…