Senior Associate Scientist, Cell Therapy

Job summary:

Senior Associate Scientist, Cell Therapy

Pharma Essentia Corporation is seeking a Senior Associate Scientist to join the Cell Therapy team and contribute to the development of novel immunotherapies for immunology and oncology. The successful candidate will be responsible for mRNA-based CAR T cell engineering and characterization. The successful candidate will be a highly motivated bench scientist and will be responsible for immuno-assay execution for discovery projects and technology evaluations.

They will generate data to support key decisions for project teams and actively participate in the interpretation of data and design of experiments. They will have the opportunity to work independently and collaboratively to advance portfolio programs in a dynamic and fast-paced environment.

It’s not often you get the chance to make a real impact on the lives of others, while expanding your own possibilities. You’ll find that rare opportunity n us, and let’s transform lives, together.

Pharma Essentia Corporation is a rapidly growing biopharmaceutical innovator. We are leveraging deep expertise and proven scientific principles to deliver effective new biologics for challenging diseases in the areas of hematology and oncology, with one approved product and a diversifying pipeline. We believe in the potential to improve both health and quality of life for patients with limited options today through the combination of rigorous research and innovative thinking.

Founded in 2003 by a team of Taiwanese-American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung, Taiwan.

Our new research center, Pharma Essentia Innovation Research Center (PIRC), will build upon our invention and discovery-based innovation efforts originally established in Taiwan that led to a transformative advancement for treating polycythemia vera (one of the myeloid proliferative neoplasms). At PIRC, we aim to expand our current expertise in related therapeutic areas and identify novel therapeutic approaches in early to mid-stage discovery and development.

• Perform primary immune cell isolation and culture, as well as cancer cell line culture.
• Perform mRNA-based CAR T cell engineering using electroporation and tLNP
• Lead functional characterization of CAR T cells with immunoassays
• Data analysis and thorough documentation of work in the Company’s ELN system
• Present results at team meetings, in other group settings, and at external scientific conferences
• Work cross-functionally as part of internal multi-disciplinary project teams
• Maintaining a safe and clean laboratory environment following all precautions required for a BSL2/BSL2+ setting.

• Senior Associate Scientist: B.S./M.S. in immunology, biology, oncology or related discipline with BS 6+ years or MS 4+ years of relevant industry experience
• Strong hands-on experience with primary human immune cell and cancer cell line culture, T cell transfection via mRNA electroporation, cell immunophenotyping using multicolor flow cytometry, cytotoxicity assays, multiplex ELISA, live-cell analysis using incucyte system
• Proficiency in operating instruments like BD Fortessa flow cytometer, Lonza 4D-Nucleofector, Meso Scale Discovery plate reader, xCELLigence RTCA
• Working knowledge of CAR T cell therapy discovery
• Ability to follow defined procedures and protocols, and strong attention to detail
• Proficiency with data analysis software such as Flow Jo, Graph Pad Prism, etc
• Willingness to…