Researcher-expert metabolic regulation of microglia physiology in Alzheimer’s disease

Organisation/Company Hasselt University Research Field Medical sciences Researcher Profile First Stage Researcher (R1) Positions PhD Positions Final date to receive applications 2 Mar 2026 - 12:00 (Europe/Brussels) Country Belgium Type of Contract Temporary Job Status Full-time Hours Per Week 38 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Reference Number 256/BAP/006 Is the Job related to staff position within a Research Infrastructure?

No

Your function

We are seeking a highly motivated postdoctoral researcher to strengthen our dynamic research team. Our research group investigates the role of lipid metabolism in neurological and autoimmune diseases, with a particular focus on neuroinflammation and brain repair ( ).

A major research line focuses on microglia, the resident immune cells of the central nervous system. Previous work from our group has demonstrated that disturbances in fatty acid metabolism can drive microglia toward a disease-promoting phenotype. In this project, we build on these findings by investigating how a post-translational modification known as S-acylation - whereby fatty acids are covalently attached to proteins - modulates microglial physiology and function in the context of Alzheimer’s disease.

In addition, we examine whether targeted modulation of these modifications can help slow disease progression.

You will employ state-of-the-art methods and model systems, including iPSC-derived microglia and patient material, animal models, advanced omics approaches (such as lipidomics, proteomics, and RNA sequencing), molecular and metabolic analyses, immunohistochemistry, and multicolor flow cytometry. In addition to conducting high-quality research, you will supervise PhD and master’s students, actively contribute to grant writing, and participate in teaching activities.

Your team

The Faculty of Medicine and Life Sciences contributes to sustainable solutions for health-related issues as part of Hasselt University's civic mission. The faculty focuses on excellence in education and research, and connects with society through a strong collaboration with our partners. Starting from continuous attention to quality and innovation, the faculty serves as a breeding ground and a magnet for talent, with an open view on society, from the region to the world.

The Biomedical Research Institute (BIOMED) of Hasselt University conducts high level multidisciplinary research to advance progress in human life sciences. Using state of the art technologies, BIOMED generates novel insights in three main disease areas: neuroscience, immunology and cardiometabolic science. BIOMED aims to translate new scientific discoveries into applications that contribute to a healthy society in line with the civic ambition of Hasselt University.

• You hold a PhD in (bio) medical sciences, biochemistry, or an equivalent degree. Doctoral students in their final year may also apply.
• You have a proven track record of publications relevant to the research theme.
• Expertise in iPSC-derived microglia is an asset.
• Expertise in Alzheimer’s disease pathology, lipid metabolism, and omics data analysis is an asset
• You are able to conduct research both independently and as part of a team.
• You have excellent writing and communication skills in English.
• You possess strong problem-solving skills.
• You are motivated to apply for a personal grant (Marie Curie, EMBO, or national funding organizations).

You will be appointed and paid as Researcher-expert .
We offer a one-year contract, with the possibility of extension, after a positive evaluation.

The selection procedure consists of a preselection based on application file and an interview.