Manufacturing Senior Manager, Liso-cel CAR-T, Manufacturing Operations

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits.

This is work that transforms the lives of patients, and the careers of those who do it. At Bristol Myers Squibb we are reimagining the future of cell therapy. With our bold ambition, backed by a best-in-the-industry team and long-term commitment, we are leading the way to unlock the full promise of cell therapy as we strive to put more patients on the path to a cure.

If you are ready to challenge yourself, accelerate your career, and give new hope to patients, there’s no better place than here at BMS with our Cell Therapy team.

The Senior Manager, Manufacturing provides oversight of Manufacturing Managers and Work Centered Teams operating on a 24/7 schedule to execute Cell Therapy manufacturing processes while sustaining a culture of safety, compliance, accountability, innovation, urgency, passion, and continuous improvement. This role reports to the Manufacturing Associate Director. Shift Available:
Saturday-Wednesday, Onsite Night Shift, 11:30 p.m.

- 8 a.m.

Ensure Manufacturing Managers and WCT members execute Cell Therapy manufacturing in compliance with cGMPs, approved SOPs, WIs, batch records, safety expectations, and ALCOA+ documentation principles. Maintain hands-on process expertise across unit operations, support MRB data collection, provide weekend/technical coverage as needed, and develop CAR-T manufacturing and regulatory knowledge. Manage production resources by tracking availability, supporting scheduling needs, maintaining records of planned/unplanned absences, and hiring talent aligned with job requirements, budget, and BMS values.

Set priorities, establish WCT goals, monitor performance, and report metrics and progress through Tier meetings, performance reviews, site control plans, and cross-functional manufacturing forums. Maintain 100% on-time training compliance, ensure personnel are qualified before performing tasks, allocate time for training, and disqualify personnel from GMP tasks when compliance gaps are observed. Build and develop high-performing teams through recruiting, onboarding, Workday profile maintenance, performance management, recognition, coaching, regular 1:1s, career development, and timely feedback.

Lead deviation troubleshooting and quality record ownership as BPO/BTA, ensure clear and timely deviation entries, monitor metrics, identify repeat causes, drive on-time closure, and prevent recurrence through continuous improvement. Participate in CAPAs, Change Controls, and projects; define or own actions for Manufacturing and ensure implementation before due dates. Control expenses within area of influence, including overtime, supplies, and travel/expense costs.

Model leader behaviors by maintaining shopfloor presence, conducting Gemba/Go & See activities, using tiered management, visual management, coaching kata, root-cause problem solving, risk escalation, and cross-functional collaboration.

Extensive knowledge of EHS, cGMPs, biotechnology principles, manufacturing systems, lean manufacturing, and regulated operations;
Green Belt certification preferred. Strong communication, adaptability, strategic leadership, team selection, and people management skills.

Bachelor’s degree in a related field preferred, or equivalent work experience;…