Senior Clinical Research Scientist II

Caribou Biosciences is a leading clinical-stage CRISPR genome-editing biopharmaceutical company dedicated to developing transformative therapies for patients with devastating diseases. Our next-generation genome-editing technology enables superior precision to develop cell therapies that are armored to potentially improve activity against diseases. We believe the future of cell therapy is off-the-shelf, and we are advancing our pipeline of off-the-shelf, or allogeneic, cell therapies from our CAR-T cell therapy platform as readily available treatments for patients with hematologic malignancies and autoimmune diseases.

Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, and contributions are recognized. Members of the herd work from our headquarters in Berkeley, California, or remotely.

The Senior Clinical Research Scientist II plays a key role in the clinical development of allogeneic CAR-T therapies for hematologic malignancies, including lymphoma, leukemia, and multiple myeloma. They are responsible to lead study-level activities and contribute to clinical strategy, driving the design, execution, and interpretation of early-phase clinical trials. The candidate is expected to partner cross-functionally to ensure high-quality data generation, advance innovative therapies, and support regulatory submissions.

• Lead clinical study in execution, including planning, conduct, data review, and reporting for Phase I and II trials in hematologic malignancies
• Own ongoing clinical data review, ensuring patient safety and data integrity; identify trends and drive data informed decisions
• Lead safety monitoring activities including review of adverse events and CAR-T associated toxicities (ie: CRS, ICANS) and contribute to dose escalation decisions
• Drive cross-functional collaboration with Clinical Operations, Translational Sciences, Data Management, Biostatistics, Regulatory, and CMC teams to ensure high-quality study execution
• Lead authorship of key study documents, including protocols, Investigator’s Brochures, clinical study reports, regulatory documents, and safety narratives
• Integrate clinical and translational data(ie: cell expansion, persistence, biomarker data) to generate insights and inform program strategy
• Contribute to regulatory strategy and submissions, including IND-related documents and health authority responses
• Serve as a scientific lead at the study level, engaging with investigators, CROs, and key opinion leaders
• Support development of publications, abstracts, and presentationsfor scientific conferences
• Ensure compliance with GCP, internal SOPs, and regulatory requirements

• PhD/Pharm
  
  D with 5+ years of experience in clinical development; MA/MS/MSN and 8+ years of experience; BA/BS/BSN and 10+ years of experience
• Experience with CAR-T or cell therapy development
• Demonstrated ownership of clinical studies, preferably early phase trials
• Strong scientific writing and communication skills
• Experience with GCP and regulatory requirements
• Experience with clinical data review and interpretation (including data listings)
• Ability to analyze and synthesize complex clinical and biomarker data
• Ability to travel 30% based on business needs

• Experience in fast paced biotech environment
• Experience with product launch or late stage development activities

• Comprehensive compensation package, which includes competitive salary, bonus, and equity for all employees
• Salary Range: $215,000 - $230,000. This represents the present low and high end of the Company’s pay range for this position. Actual pay will vary based on various factors, including but not limited to location, skill, experience, and performance.
• Generous paid vacation time, in addition to company-observed holidays
• Excellent medical, dental, and vision insurance
• 401(k) retirement savings plan, which includes matching employer contributions
• Employee stock purchase plan (ESPP)

Caribou is an equal opportunity employer and does not discriminate…