Director, Scientific Operations

About Glyphic

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

Glyphic is seeking a scientifically rigorous, pragmatic, and execution‑driven leader for a Director of Scientific Operations
, reporting to the VP of R&D.

The Director of Scientific Operations will own the preparation, stabilization, and management of evaluation‑grade reagents and scientific operations that enable reliable execution of our single‑molecule protein sequencing platform. This role works closely with the Director of Chemistry and the Director of Assay Development to translate novel chemical components and reagents into stockable, assay‑ready units, and to collaboratively understand which reagent attributes are most important for assay performance.

This is a hands‑on leadership role focused on scientific judgment, speed, and reproducibility in an early‑stage R&D environment. Characterization is intentionally fit‑for‑purpose and evolves alongside assay understanding.

The ideal candidate brings strong operational and scientific judgment, clearly distinguishing which reagent attributes matter—and which do not—for assay performance, while building fit‑for‑purpose operational frameworks that enable chemistry inventions to be translated into usable, reproducible reagents without unnecessary delay or over‑characterization.

This role offers a unique opportunity to define and lead scientific operations at a formative stage, ensuring reagent knowledge, operational infrastructure, and assay understanding evolve in lockstep to support the company’s next‑generation protein sequencing platform.

This is a full‑time, exempt, in‑person position with work conducted at our Berkeley, CA location.

• Prepare, formulate, stabilize, and stock evaluation‑grade reagents and buffers required for sequencing assays
• Establish storage conditions, handling practices, and refresh strategies that preserve assay‑relevant performance
• Design and run fit‑for‑purpose stability studies to understand how reagents change over time and under different conditions
• Produce and manage reagent and assay‑ready consumable inventories sufficient to support ongoing experiments, demos, and early evaluations

• Work with Chemistry and Assay teams to identify which reagent attributes matter most for assay performance (e.g., purity, activity, labeling efficiency, degradation modes)
• Perform and coordinate targeted, hypothesis‑driven characterization to inform assay interpretation and reagent handling
• Translate experimental observations into practical guidance for reagent preparation, storage, and use
• Avoid premature or exhaustive characterization that does not inform assay performance

• Partner closely with the Director of Chemistry to understand chemical design intent and expected behavior
• Partner closely with the Director of Assay Development to ensure reagents meet assay needs and constraints
• Translate chemistry prototypes into repeatable, reproducible reagent preparation workflows
• Identify sources of reagent variability and drive scientific root‑cause analysis in collaboration with chemistry and assay teams

• Develop lightweight documentation for reagent preparation, stabilization, storage, and usage; translate R&D protocols into fit‑for‑purpose SOPs as needed
• Build and maintain lab infrastructure required for reagent preparation and storage
• Oversee facilities operations as they relate to R&D, serving as the connective tissue between scientific operations and facilities
• Negotiate terms and manage relationships with vendors and service providers; ensure consumables, equipment, lab spaces, and utilities support…