Director, Scientific Operations Berkeley, CA

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single‑molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non‑dilutive grant funding to achieve our vision of next generation proteome sequencing.

Glyphic is seeking a scientifically rigorous, pragmatic, and execution‑driven leader for a Director of Scientific Operations, reporting to the VP of R&D.

• Prepare, formulate, stabilize, and stock evaluation‑grade reagents and buffers required for sequencing assays
• Establish storage conditions, handling practices, and refresh strategies that preserve assay‑relevant performance
• Design and run fit‑for‑purpose stability studies to understand how reagents change over time and under different conditions
• Produce and manage reagent and assay‑ready consumable inventories sufficient to support ongoing experiments, demos, and early evaluations
• Work with Chemistry and Assay teams to identify which reagent attributes matter most for assay performance (e.g., purity, activity, labeling efficiency, degradation modes)
• Perform and coordinate targeted, hypothesis‑driven characterisation to inform assay interpretation and reagent handling
• Translate experimental observations into practical guidance for reagent preparation, storage, and use
• Avoid premature or exhaustive characterisation that does not inform assay performance

• Partner closely with the Director of Chemistry to understand chemical design intent and expected behaviour
• Partner closely with the Director of Assay Development to ensure reagents meet assay needs and constraints
• Translate chemistry prototypes into repeatable, reproducible reagent preparation workflows
• Identify sources of reagent variability and drive scientific root‑cause analysis in collaboration with chemistry and assay teams

• Develop lightweight documentation for reagent preparation, stabilisation, storage, and usage; translate R&D protocols into fit‑for‑purpose SOPs as needed
• Build and maintain lab infrastructure required for reagent preparation and storage
• Oversee facilities operations as they relate to R&D, serving as the connective tissue between scientific operations and facilities
• Negotiate terms and manage relationships with vendors and service providers; ensure consumables, equipment, lab spaces, and utilities support evolving R&D needs
• Serve as the scientific owner for reagent readiness prior to any future manufacturing transition
• Ensure equipment functionality, inventory and supply management, safety compliance, and other logistical functions of a research laboratory

• Lead and mentor a small team (approximately 2 people) supporting reagent preparation and general lab stocking
• Oversee day‑to‑day lab readiness, including consumables, buffers, and shared reagent availability
• Establish lightweight processes to keep the lab running smoothly without over‑engineering

Required :

• BS/MS degree in Chemistry, Chemical Biology, Biochemistry, Engineering, or a related discipline
• 7–10+ years of relevant industry experience supporting R&D teams in scientific operations
• Proven experience managing reagent inventory, forecasting demand, and preventing stock‑outs for active R&D programmes
• Deep hands‑on experience with reagent preparation, formulation, stabilisation, and fit‑for‑purpose characterisation, including translating R&D protocols into usable SOPs
• Familiarity with sequencing or broader omics workflows, including custom reagents, consumables, and specialised equipment
• Demonstrated people‑leadership experience, including supervising staff and reporting forecasts, plans, and risks to management
• Strong negotiation skills with external vendors, including securing favourable contract terms, pricing, and supply agreements
• Experience collaborating with procurement and accounting functions (e.g.,…