Research Associate, Biotech Research, Research Scientist

The heart of Prellis Bio’s strategy is the combination of novel, cutting-edge methods in machine learning, biology at scale, and next-gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids, enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.

To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

We are seeking a Senior Research Associate — High-Throughput (HTP) Antibody Production to join our High Throughput Discovery group. You will scale our automated antibody expression and purification pipelines to accelerate biotherapeutic discovery efforts.

• Innovate and implement our HTP antibody production pipeline — expression, purification, and QC — delivering high-quality antibodies from our EXIS and AI/ML platforms for early screening.
• Maintaining cell lines and reagents to ensure consistent and reliable weekly antibody production for downstream testing.

The ideal candidate will thrive in a dynamic environment and play a critical role in delivering life-changing therapeutics.

• Perform small-scale HTP expression & Protein A purifications using the King Fisher and Bio Mek i7
• Perform weekly HTP antibody expressions of 500+ antibodies per week
• Support midscale antibody production
• Manage antibody inventory and hand-offs to downstream colleagues
• Automate new lab processes for multiple teams
• Maintain cell lines for HTP and large-scale antibody production
• Optimize antibody production for maximal scale, speed, and yield
• Perform quality control of high-throughput productions using CE-SDS
• Maintain accurate ELN documentation
• Communicate results and support cross-team workflows
• Monitor expression titers (Octet, Forte Bio, or comparable); perform post-purification buffer exchange, concentration, and aliquoting for downstream handoff.
• Track and report production KPIs (yields, purification recovery, quality).

• BS in Biochemistry, Molecular Biology, or a related field with 3+ years of relevant industry experience
• Excellent interpersonal skills; desire to learn new techniques and wear multiple hats
• Demonstrated experience in protein expression and purification, preferably in HTP
• Experience with automated or semi-automated liquid handlers (Biomek i7, King Fisher, Lynx, Integra Via Flo, etc.)
• Strong understanding of therapeutic antibody discovery process
• Strong organizational skills, attention to detail, and ability to drive multiple projects
• Demonstrated experience collaborating across scientific disciplines in a dynamic environment
• Keen interest in pushing the envelope on HTP production scale and capacity
• Hands-on experience with mammalian cell culture (CHO, HEK, Expi, or equivalent) — including transfection, cell maintenance, and titer monitoring.
• Experience with analytical QC of proteins/antibodies (CE-SDS, HPLC, aSEC, or comparable) for purity and quality assessment.

• Familiarity with protein QC on LC/MS and aSEC
• Experience with multiple antibody formats (human IgG, bispecific, Fc fusion)
• Method development on automated liquid handlers (Biomek Method Editor, King Fisher scripts, Tecan, or equivalent).
• Experience with midscale or bioreactor-based expression (fed-batch, perfusion, or ≥100 mL culture).
• Prior industry experience running 100+ antibody productions per week in an HTP setting.

At Prellis we integrate human biology with machine learning. We aim to revolutionize drug discovery by harnessing the power of the human immune system with tightly integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision, and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human antibody candidates rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.

Prellis…