Senior Research Associate-Associate Scientist

High-Throughput Antibody Discovery

Function: High Throughput Discovery group

The heart of Prellis Bio’s strategy is the combination of novel, cutting-edge methods in machine learning, biology at scale, and next-gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids, enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.

To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

Position Summary

We are seeking a Senior Research Associate / Associate Scientist — High-Throughput Antibody Discovery to join our dynamic team. You will execute and evolve our state-of-the-art molecular biology, NGS, and end-to-end automation pipelines that fuel antibody discovery. You will be responsible for:

• Executing HTP molecular biology and NGS workflows — plasmid generation, PCR / cloning / mutagenesis, DNA library construction, and single-cell NGS (10x Genomics, CITE-Seq) — to enable antibody discovery.
• Driving automation and platform innovation — developing and scaling end-to-end automation pipelines and contributing to continuous improvement of our discovery workflows.

This role sits within a highly cross-functional High Throughput Discovery group, with significant opportunities to grow and take on new responsibilities. The ideal candidate is hands-on, curious, and driven to innovate — thriving in a dynamic, fast-paced environment while playing a critical role in delivering life-changing therapeutics.

• Execute high-throughput molecular biology workflows, including plasmid generation, PCR, cloning, mutagenesis, and DNA library construction, to support antibody discovery.
• Build and run end-to-end automation pipelines on liquid handlers (Biomek, King Fisher, or similar) to scale throughput across molecular biology and genomics workflows.
• Execute high-throughput workflows to probe immune repertoires from diverse discovery sources with single-cell VH-VL molecular recovery, NGS, and single-cell technologies (10x Genomics, CITE-Seq).
• Contribute to technology innovation, troubleshooting, and continuous improvement of our NGS and molecular discovery platforms.
• Apply antibody repertoire bioinformatics tools to evaluate selection outputs; collaborate with Data Science on data visualization and reporting.
• Maintain accurate ELN documentation and communicate results clearly across teams.
• Interface with external vendors and CROs (e.g., gene synthesis, sequencing services) to support antibody discovery workflows.
• Support cross-functional collaboration across therapeutic programs and technology initiatives.

• BS or MS in Molecular Biology, Biochemistry, Genetics, Immunology, or related field with equivalent industry experience:
  Sr. Research Associate (BS + 3–5 yrs, or MS + 0–2 yrs);
  Associate Scientist (BS + 5+ yrs, or MS + 2+ yrs).
• Strong molecular biology fundamentals, including PCR, cloning, mutagenesis, plasmid design and generation, and DNA library construction.
• Experience with automated liquid handlers (Biomek, King Fisher, Tecan, or similar), or willingness to become proficient.
• Hands‑on experience with sample‑to‑data NGS workflows on Illumina platforms (Next Seq, MiSeq, Nova Seq, or similar), including single‑cell technologies (10x Genomics, CITE-Seq, microfluidic droplets) or comparable techniques.
• Genuine curiosity for innovation and R&D: motivated to develop, troubleshoot, and evolve new workflows.
• Strong interpersonal and communication skills; able to collaborate effectively across teams and functions in a fast‑paced environment.
• Strong organizational skills, attention to detail, and ability to work independently with minimal supervision.
• Keen to grow skillsets and continuously learn new techniques.

• Working knowledge of B cell immunology or antibody biology.
• Programming or method development on automated liquid handlers (Biomek Method Editor, King Fisher scripts, Tecan, or…