Senior Scientist - Therapeutic Antibody Characterization

Prellis Biologics is advancing next-generation antibody therapeutics by integrating machine learning, scalable biology, and proprietary 3D-printed human lymph node organoids. We are expanding our platform into complex antibody modalities to develop innovative biologic medicines, with programs spanning obesity, inflammation and immunology (I&I), and oncology
.

We are seeking an experienced Senior Scientist – Therapeutic Antibody Characterization to join our Therapeutics team. The successful candidate will lead the analytical characterization of monoclonal antibodies, bispecific antibodies, Fc-fusion proteins, and other complex biologics to support candidate selection and preclinical development. This role will apply a broad range of biochemical, biophysical, and analytical techniques to evaluate protein quality, develop ability, stability, and structure, while working closely with Antibody Discovery, Protein Engineering, and CMC teams.

• Perform comprehensive analytical characterization of therapeutic monoclonal antibodies (mAbs), bispecific antibodies, Fc-fusion proteins, and related biologics.
• Conduct biophysical and develop ability assessments using techniques including Tm, Tagg (Uncle), particle size analysis, AC-SINS, HIC, cIEF, analytical SEC (aSEC), and BVP assays.
• Generate, analyze, and interpret analytical data to support lead candidate selection, formulation development, stability studies, and analytical comparability assessments.
• Design, execute, troubleshoot, and optimize analytical methods to support therapeutic protein characterization.
• Prepare clear, accurate, and well-organized technical reports and present experimental findings to cross-functional project teams.
• Collaborate closely with scientists in Antibody Discovery & Protein Engineering
• Maintain accurate laboratory documentation and ensure compliance with laboratory safety and quality standards.

• Ph.D. or M.S. in Biochemistry, Chemistry, Molecular Biology, Pharmaceutical Sciences, or a related discipline.
• Minimum of 3 years of industry experience (or equivalent) in the analytical characterization of therapeutic antibodies, bispecific antibodies, Fc-fusion proteins, or other biologics.
• Strong hands‑on experience with protein characterization techniques, including Tm, Tagg (Uncle), AC‑SINS, HIC, cIEF, analytical SEC (aSEC), BVP, and related biochemical and biophysical assays.
• Demonstrated ability to independently design experiments, analyze data, solve technical challenges, and communicate scientific findings effectively.
• Excellent organizational, interpersonal, and written communication skills, with the ability to work effectively in a collaborative, multidisciplinary environment.

• Experience with antibody develop ability, stability profiling, and analytical comparability studies.
• Experience with LC-MS-based characterization of therapeutic antibodies, including intact mass analysis, subunit analysis, peptide mapping, and post-translational modification (PTM) analysis.
• Experience in the bioanalysis of serum and plasma samples to support pharmacokinetic (PK), pharmacodynamic (PD), and preclinical studies.
• Experience with the analytical characterization of antibody–peptide drug conjugates, including conjugation analysis, conjugate purity, drug loading, and stability assessment.
• Knowledge of regulatory expectations and analytical strategies supporting therapeutic biologics development.

At Prellis we integrate human biology with machine learning. We aim to revolutionize drug discovery by harnessing the power of the human immune system with tightly integrated machine learning to develop next‑generation antibody therapeutics with unparalleled speed, precision, and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human antibody candidates rapidly identified from the human immune repertoire, enabling them to bring life‑changing treatments to patients faster than ever before.

Prellis Biologics is a pre‑IPO biotech located in Berkeley, CA with a team‑oriented, inclusive, and family‑friendly…