Scientist-Senior Scientist-Bioanalysis

The heart of Prellis Bio’s strategy is the combination of novel, cutting-edge methods in machine learning, biology at scale, and next-gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids, enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.

Our growing pipeline spans obesity, inflammation and immunology (I&I), and oncology. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

We are seeking a Scientist / Senior Scientist — Bioanalysis to join our Protein Sciences group
. You will develop and execute bioanalytical assays that support molecular characterization, PK/PD, and preclinical development of Prellis’s next-generation biologic candidates, including antibody-peptide conjugates, bispecific/multispecific antibodies, and Fc-fusion proteins. You will be responsible for:

• Leading bioanalytical method development
  : ELISA/LBA, LC-MS, and HRMS assays to characterize, quantify, and profile complex biologic modalities from discovery through biopreclinical.
• Enabling PK/PD and stability programs
  : analyzing serum/plasma samples, distinguishing intact conjugates from free components and degradation products, and supporting candidate selection with rigorous data.

This role sits at the intersection of Protein Sciences, Analytical Development, DMPK, CMC, and Pharmacology
, and will characterize antibodies produced from our discovery platform and enable their transition to preclinical development. The ideal candidate will thrive in a dynamic, hands‑on environment and play a critical role in delivering life‑changing therapeutics.

• Develop and optimize bioanalytical assays for antibody‑peptide conjugates, bispecific antibodies, and Fc‑fusion proteins.
• Select format‑appropriate LBA and MS approaches aligned to the antibody formats coming out of Prellis’s discovery platform.
• Develop and execute ELISA/LBA and LC‑MS/HRMS‑based assays for characterization and quantification of biologic molecules.
• Analyze serum/plasma samples from preclinical and in‑vivo studies to support PK/PD and exposure assessments.
• Develop assays to distinguish intact conjugates, free antibody/protein, free peptide, and degradation products.
• Characterize biologic integrity, stability, and relevant molecular attributes using appropriate analytical and bioanalytical approaches.
• Support assay qualification/validation and generate high‑quality technical documentation.
• Collaborate with Protein Engineering, CMC, Analytical Development, DMPK, and Pharmacology teams to support candidate selection and development.
• Partner closely with the High Throughput Discovery group (Antibody Protein Engineering, Discovery, and Production teams) on early bioanalytical support for lead candidates transitioning from discovery to development.
• Support external CROs and analytical vendors as needed.
• Deploy and scale automated workflows on liquid handlers (Hamilton, Tecan, Biomek, or similar) to increase bioanalytical throughput.
• Establish assay and data handoff workflows between High Throughput Discovery and Protein Sciences to enable seamless candidate progression from screening to preclinical characterization.

• Ph.D. or M.S. in Bioanalytical Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related field.
  • oScientist level (PhD + 0–3 years relevant industry experience) or Senior Scientist level (PhD + 3–6 years direct relevant industry experience); MS with additional years of relevant industry experience also considered.
• Hands‑on experience with bioanalytical assay development for biologics, antibodies, peptides, or proteins.
• Experience with one or more of ELISA/LBA, LC‑MS/MS, LC‑HRMS, or related bioanalytical technologies.
• Hands‑on experience with mass spectrometry (e.g., Sciex Triple Quad) and ligand‑binding assay platforms (e.g., MSD).
• Experience with PK/PD, serum/plasma bioanalysis, and preclinical…