Senior Research Associate-Associate Scientist- Throughput Antibody Discovery

Senior Research Associate / Associate Scientist

Function: High Throughput Discovery

The heart of Prellis Bio’s strategy is the combination of novel, cutting‑edge methods in machine learning, biology at scale, and next‑gen antibody discovery that address long‑standing industry‑wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids, enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.

To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

We are seeking a Senior Research Associate / Associate Scientist — High-Throughput Antibody Discovery to join our dynamic team. You will execute and evolve our state‑of‑the‑art molecular biology, NGS, and end‑to‑end automation pipelines that fuel antibody discovery. You will be responsible for:

• Executing HTP molecular biology and NGS workflows — plasmid generation, PCR / cloning / mutagenesis, DNA library construction, and single‑cell NGS (10x Genomics, CITE‑Seq) — to enable antibody discovery.
• Driving automation and platform innovation — developing and scaling end‑to‑end automation pipelines and contributing to continuous improvement of our discovery workflows.

This role sits within a highly cross‑functional High Throughput Discovery group, with significant opportunities to grow and take on new responsibilities. The ideal candidate is hands‑on, curious, and driven to innovate — thriving in a dynamic, fast‑paced environment while playing a critical role in delivering life‑changing therapeutics.

• Execute high‑throughput molecular biology workflows, including plasmid generation, PCR, cloning, mutagenesis, and DNA library construction, to support antibody discovery.
• Build and run end‑to‑end automation pipelines on liquid handlers (Biomek, King Fisher, or similar) to scale throughput across molecular biology and genomics workflows.
• Execute high‑throughput workflows to probe immune repertoires from diverse discovery sources with single‑cell VH‑VL molecular recovery, NGS, and single‑cell technologies (10x Genomics, CITE‑Seq).
• Contribute to technology innovation, troubleshooting, and continuous improvement of our NGS and molecular discovery platforms.
• Apply antibody repertoire bioinformatics tools to evaluate selection outputs; collaborate with Data Science on data visualization and reporting.
• Maintain accurate ELN documentation and communicate results clearly across teams.
• Interface with external vendors and CROs (e.g., gene synthesis, sequencing services) to support antibody discovery workflows.
• Support cross‑functional collaboration across therapeutic programs and technology initiatives.

• BS or MS in Molecular Biology, Biochemistry, Genetics, Immunology, or related field with equivalent industry experience:
  Sr. Research Associate (BS + 3–5 yrs, or MS + 0–2 yrs);
  Associate Scientist (BS + 5+ yrs, or MS + 2+ yrs).
• Strong molecular biology fundamentals, including PCR, cloning, mutagenesis, plasmid design and generation, and DNA library construction.
• Experience with automated liquid handlers (Biomek, King Fisher, Tecan, or similar), or willingness to become proficient.
• Hands‑on experience with sample‑to‑data NGS workflows on Illumina platforms (Next Seq, MiSeq, Nova Seq, or similar), including single‑cell technologies (10x Genomics, CITE‑Seq, microfluidic droplets) or comparable techniques.
• Genuine curiosity for innovation and R&D: motivated to develop, troubleshoot, and evolve new workflows.
• Strong interpersonal and communication skills; able to collaborate effectively across teams and functions in a fast‑paced environment.
• Strong organizational skills, attention to detail, and ability to work independently with minimal supervision.
• Keen to grow skillsets and continuously learn new techniques.

• Working knowledge of B cell immunology or antibody biology.
• Programming or method development on automated liquid handlers (Biomek Method Editor, King Fisher scripts,…