Principal Associate Scientist-Scientist Throughput Screening

About the job

The heart of Prellis Bio’s strategy is the combination of novel, cutting‑edge methods in machine learning, biology at scale, and next‑gen antibody discovery that address long‑standing industry‑wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids, enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.

Our growing pipeline spans obesity, inflammation and immunology (I&I), and oncology. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

We are seeking aPrincipal Associate Scientist / Scientist — High-Throughput Screening to join our High Throughput Discovery group. You will apply high-throughput platforms to identify lead antibody candidates earlier and faster from immunization campaigns. You will be responsible for:

• Running end-to-end primary cell screening: isolating B cells and plasma cells from immunization campaigns and leveraging single‑cell platforms (such as 10x Genomics and microfluidics) to identify antigen‑specific B cells.
• Developing and executing primary supernatant screens: ELISA and cell‑based assays to characterize antibodies expressed by mammalian cells in secretion.

This role sits within a highly cross‑functional High Throughput Discovery group, with significant opportunities to grow and take on new responsibilities. The ideal candidate will thrive in a dynamic, hands‑on environment and play a critical role in delivering life‑changing therapeutics.

• Isolate and enrich B cells and plasma cells from immunization campaigns, and leverage single‑cell platforms (such as 10x Genomics and microfluidics) to identify antigen‑specific B cells.
• Develop, execute, and optimize primary screens (ELISA and cell‑based assays on iQue) to characterize antibodies expressed by mammalian cells in secretion.
• Scale high‑throughput screening strategies for binder discovery from Prellis’s discovery platforms.
• Evaluate and pilot emerging technologies and experimental workflows to enhance discovery capabilities.
• Develop and optimize automated workflows to ensure data quality, reproducibility, and process efficiency.
• Partner with Antibody Protein Engineering, Discovery, Production, and Data Science / AI/ML teams to analyze, interpret, and share insights from screening data.
• Independently manage multiple projects, ensuring timely delivery of high‑quality data and adherence to team goals.
• Maintain accurate ELN documentation and communicate results clearly across internal and external scientific audiences.

• Principal Associate Scientist level: BSc/MSc in a related field with 4+ years of direct relevant industry experience. Level can be adjusted based on experience.
• Scientist level:
  PhD in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or related field (postdoctoral or industry experience welcome).
• Hands‑on experience developing primary screens using ELISA and on‑cell or cell‑based assays (iQue or comparable).
• Experience isolating and enriching B cells or plasma cells, including hands‑on operation of a FACS sorter (Sony MA900 preferred, or comparable).
• Strong competence handling primary cells (primary lymphocytes, PBMCs, or comparable), including aseptic technique, viability management, and downstream sample handling.
• Proficiency in core molecular biology techniques (cloning, PCR), mammalian cell culture, and transient transfection.
• Strong analytical skills and ability to troubleshoot complex experimental issues independently.
• Ability to analyze experimental…