Principal Associate Scientist-Scientist Throughput Screening

Principal Associate Scientist-Scientist High Throughput Screening

Full Time

High Throughput Screening

About the job

The heart of Prellis Bio’s strategy is the combination of novel, cutting-edge methods in machine learning, biology at scale, and next-gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids, enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.

Our growing pipeline spans obesity, inflammation and immunology (I&I), and oncology. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

Position Summary

We are seeking aPrincipal Associate Scientist / Scientist — High-Throughput Screening to join our High Throughput Discovery group. You will apply high-throughput platforms to identify lead antibody candidates earlier and faster from immunization campaigns. You will be responsible for:

• Running end-to-end primary cell screening: isolating B cells and plasma cells from immunization campaigns and leveraging single-cell platforms (such as 10x Genomics and microfluidics) to identify antigen‑specific B cells.
• Developing and executing primary supernatant screens: ELISA and cell‑based assays to characterize antibodies expressed by mammalian cells in secretion.

This role sits within a highly cross‑functional High Throughput Discovery group, with significant opportunities to grow and take on new responsibilities. The ideal candidate will thrive in a dynamic, hands‑on environment and play a critical role in delivering life‑changing therapeutics.

Responsibilities

• Isolate and enrich B cells and plasma cells from immunization campaigns, and leverage single‑cell platforms (such as 10x Genomics and microfluidics) to identify antigen‑specific B cells.
• Develop, execute, and optimize primary screens (ELISA and cell‑based assays on iQue) to characterize antibodies expressed by mammalian cells in secretion.
• Scale high‑throughput screening strategies for binder discovery from Prellis’s discovery platforms.
• Evaluate and pilot emerging technologies and experimental workflows to enhance discovery capabilities.
• Develop and optimize automated workflows to ensure data quality, reproducibility, and process efficiency.
• Partner with Antibody Protein Engineering, Discovery, Production, and Data Science / AI/ML teams to analyze, interpret, and share insights from screening data.
• Independently manage multiple projects, ensuring timely delivery of high‑quality data and adherence to team goals.
• Maintain accurate ELN documentation and communicate results clearly across internal and external scientific audiences.

Qualifications

• Principal Associate Scientist level: BSc/MSc in a related field with 4+ years of direct relevant industry experience. Level can be adjusted based on experience.
• Scientist level:
  PhD in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or related field (postdoctoral or industry experience welcome).
• Hands‑on experience developing primary screens using ELISA and on‑cell or cell‑based assays (iQue or comparable).
• Experience isolating and enriching B cells or plasma cells, including hands‑on operation of a FACS sorter (Sony MA900 preferred, or comparable).
• Strong competence handling primary cells (primary lymphocytes, PBMCs, or comparable), including aseptic technique, viability management, and downstream sample handling.
• Proficiency in core molecular biology techniques (cloning, PCR), mammalian cell culture, and transient transfection.
• Strong analytical skills and…