Structural Biology Scientist: Cryo-EM & Protein Design
Listed on 2026-07-08
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Research/Development
Research Scientist, Biotech Research
What You Will Do
We are seeking a Structural Biology Research Scientist to support the National Institute of Allergy and Infectious Diseases (NIAID) through viral protein construct design, expression optimization, protein purification, and cryo-electron microscopy studies that advance vaccine development. Ideal candidates will bring structural virology experience and skills in assay development, data analysis, reporting, and mentorship. This is a full-time, on-site opportunity in Bethesda, MD.
Job Family
Biologist
Travel Required
None
Clearance Required
Ability to Obtain Public Trust
What You Will Do
We are seeking a Structural Biology Research Scientist to support the National Institute of Allergy and Infectious Diseases (NIAID) through viral protein construct design, expression optimization, protein purification, and cryo-electron microscopy studies that advance vaccine development. Ideal candidates will bring structural virology experience and skills in assay development, data analysis, reporting, and mentorship. This is a full-time, on-site opportunity in Bethesda, MD.
Responsibilities
- Design and generate expression constructs for viral proteins (e.g., envelope glycoproteins, capsid proteins, regulatory proteins).
- Develop and optimize expression systems (mammalian, insect, or stable cell lines).
- Purify proteins using chromatography methods (affinity, SEC, ion exchange).
- Perform binding and antigenicity assays (e.g., ELISA, BLI, SPR)
- Conduct biochemical and biophysical characterization (e.g., SEC-MALS, DLS)
- Prepare samples and optimize vitrification conditions for cryo-EM studies
- Operate and/or coordinate use of cryo-EM instruments (e.g., Titan Krios, Glacios)
- Prepare technical reports, figures, and manuscripts
- PhD in Structural Biology or a related field
- Microsoft Office
- Technical experience needed to assist in studying the basic principles of plant and animal life.
- Technical support and troubleshooting of sophisticated equipment.
- At least 2 (two) years of experience
- Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred
- Previous experience supporting NIH
What We Offer
Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits Include
- Medical, Rx, Dental & Vision Insurance
- Personal and Family Sick Time & Company Paid Holidays
- Parental Leave
- 401(k) Retirement Plan
- Group Term Life and Travel Assistance
- Voluntary Life and AD&D Insurance
- Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
- Transit and Parking Commuter Benefits
- Short-Term & Long-Term Disability
- Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
- Employee Referral Program
- Corporate Sponsored Events & Community Outreach
- annual membership
- Employee Assistance Program
- Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and protection, etc.)
- Position may be eligible for a discretionary variable incentive bonus
Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.
Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.
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