Bioinformatics Scientist

Job Family
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Travel Required
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Clearance Required
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What You Will Do:

We are looking for a Bioinformatics Scientist (Scientist V) in the IBIS Core to support the Vaccine Research Center (VRC) at NIAID through advanced computational biology and bioinformatics analysis. This position is a full-time position located in Bethesda, MD.

• Implement and utilize workflows for next generation sequencing (NGS), including quality control (QC) and data analysis.
• Initiate interdisciplinary collaborations with scientists from other organizations or institutions engaged in related research.
• Provide scientific mentorship and guidance to students, postdoctoral fellows, technicians, and other staff in developing bioinformatics pipelines, particularly for spatial transcriptomics applications.
• Provide programming and troubleshooting support to the Federal Government in the dissemination of research data.
• Perform computational analysis of research datasets and identify trends and patterns.
• Collaborate with multidisciplinary teams to design, analyze, manage, and interpret complex biological data.
• Maintain detailed documentation of analyses and present results at laboratory meetings.
• Develop novel computational programs and algorithms to facilitate discovery in large and complex datasets.
• Evaluate and adapt bioinformatics techniques based on scientific literature, available resources, and research objectives.
• Collaborate with experimentalists and computational scientists to develop new computational tools for scientific discovery.
• Independently coordinate training of personnel on scientific, statistical, and programmatic software applications.
• Present research findings at internal meetings, conferences, and seminars; contribute to scientific publications.
• Attend scientific and programming meetings and maintain organized records of findings and discussions.

• Master’s Degree in Bioinformatics, Computational Biology, or a related discipline.
• A minimum of TWO (2) years of experience working with large, multimodal single-cell datasets.
• Proficiency in Python and R programming languages.
• Practical knowledge of and experience working with SLURM-managed high-performance computing (HPC) clusters.
• Strong analytical, statistical, and problem-solving skills.
• Experience with next generation sequencing (NGS) workflows and data analysis.
• Ability to collaborate effectively in a multidisciplinary research environment.
• Strong written and verbal communication skills, including presentation of scientific data.
• Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

• Ph.D. in Bioinformatics, Computational Biology, or a related discipline preferred.
• Experience with Xenium and/or Visium spatial transcriptomics platforms is preferred.
• Familiarity with adaptive immune receptor repertoires and general immunology are beneficial.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care,…