Structural Biology Research Scientist Jobs

Structural Biology Research Scientist

We are seeking a Structural Biology Research Scientist to support the National Institute of Allergy and Infectious Diseases (NIAID) through viral protein construct design, expression optimization, protein purification, and cryo-electron microscopy studies that advance vaccine development. Ideal candidates will bring structural virology experience and skills in assay development, data analysis, reporting, and mentorship. This is a full-time, on-site opportunity in Bethesda, MD.

Responsibilities:

• Design and generate expression constructs for viral proteins (e.g., envelope glycoproteins, capsid proteins, regulatory proteins).
• Develop and optimize expression systems (mammalian, insect, or stable cell lines).
• Purify proteins using chromatography methods (affinity, SEC, ion exchange).
• Perform binding and antigenicity assays (e.g., ELISA, BLI, SPR)
• Conduct biochemical and biophysical characterization (e.g., SEC-MALS, DLS)
• Prepare samples and optimize vitrification conditions for cryo-EM studies
• Operate and/or coordinate use of cryo-EM instruments (e.g., Titan Krios, Glacios)
• Prepare technical reports, figures, and manuscripts

What You Will Need:

• PhD in Structural Biology or a related field
• Microsoft Office
• Technical experience needed to assist in studying the basic principles of plant and animal life.
• Technical support and troubleshooting of sophisticated equipment.
• At least 2 (two) years of experience
• Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred

What Would Be Nice To Have:

• Previous experience supporting NIH

The annual salary range for this position is $85,000.00-$. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace. Benefits include:

• Medical, Rx, Dental & Vision Insurance
• Personal and Family Sick Time & Company Paid Holidays
• Parental Leave
• 401(k) Retirement Plan
• Group Term Life and Travel Assistance
• Voluntary Life and AD&D Insurance
• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
• Transit and Parking Commuter Benefits
• Short-Term & Long-Term Disability
• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
• Employee Referral Program
• Corporate Sponsored Events & Community Outreach
• annual membership
• Employee Assistance Program
• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and  protection, etc.)
• Position may be eligible for a discretionary variable incentive bonus