Chemical Biologist

** Job Family**  **:*
* Scientist

** Travel Required**  **:*
* None

** Clearance Required**  **:*
* Ability to Obtain Public Trust

** What You Will Do**  **:*
* We are currently searching for a Chemical Biologist to provide support services to satisfy the overall operational objectives of the National Heart, Lung, and Blood Institute (NHLBI).  This is a full-time, on-site opportunity in Bethesda, MD.

+ Synthesize and optimize small cyclic peptides for diagnostic imaging and early-stage drug discovery applications.

+ Design and develop small molecules as chemical tools to support biological research, including target validation and imaging (MRI, optical, PET).

+ Develop and implement mRNA-based peptide expression systems for cyclic peptide production.

+ Perform peptide conjugation, including linking to fluorescent dyes, chelators, or imaging agents.

+ Prepare and characterize antibody fragments (e.g., nanobodies, Fab2) and conjugate them for imaging applications.

+ Conduct compound screening, synthesis, and optimization workflows.

+ Utilize modern analytical instrumentation to characterize compounds and ensure quality.

+ Collaborate closely with multidisciplinary teams in a service-oriented research environment.

+ Document and communicate experimental results effectively through reports and presentations.

** What You Will Need**  **:*
* + Ph.D. in Chemistry, Biochemistry, or related field with a minimum of TWO (2) years of laboratory research experience OR Master's degree in Chemistry, Biochemistry, or related field with a minimum of FOUR (4) years of laboratory research in lieu of Ph.D.

+ Demonstrated expertise in cyclic peptide generation, screening, synthesis, and optimization.

+ Strong background in synthetic chemistry, including small molecule and peptide synthesis.

+ Knowledge of chemical biology approaches for drug discovery or imaging applications.

+

Experience with or knowledge of fluorescent dyes, chelators for radioactive metals, MRI agents and nanoparticles.

+ Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

** What Would Be Nice To Have**  **:*
* + Ability to design and execute complex experiments independently.

+ Excellent communication skills.

+ Proven ability to work effectively in a collaborative, team-based environment.

The annual salary range for this position is $98,000.00-$.  Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

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* What We Offer:

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* Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

+ Medical, Rx, Dental & Vision Insurance

+ Personal and Family Sick Time & Company Paid Holidays

+ Parental Leave

+ 401(k) Retirement Plan

+ Group Term Life and Travel Assistance

+ Voluntary Life and AD&D Insurance

+ Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

+ Transit and Parking Commuter Benefits

+ Short-Term & Long-Term Disability

+ Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

+ Employee Referral Program

+ Corporate Sponsored Events & Community Outreach

+  annual membership

+ Employee Assistance Program

+ Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and  protection, etc.)

+ Position may be eligible for a discretionary variable incentive bonus

** About Guidehouse*
* Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

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