Senior Manager – Response Threat Operations

Use Your Power for Purpose

Our Global Cyber Defense team(CD) is responsible for safeguarding Pfizer’s digital assets and infrastructure through proactive threat detection, response, and risk mitigation across on-premises, cloud, and hybrid environments.

The CD organization ispart of a broader security organization at Pfizer called CISO. TheCISOorganizationsecures Pfizer’s most important information assets through world class talent, top security controls and an empowered culture that serves to enable Pfizer’s mission of delivering breakthroughs that change patients’ lives.

The Senior Manager – Response Threat Operations will report into the Response Threat Operations team and will focus on responding to network security events and building a deep understanding of cybersecurity attacks against Pfizer. The Senior Manager – Response Threat Operations will be expected to lead event correlation across large datasets, perform and drive complete attack lifecycle analysis, develop remediation plans, implement proactive and reactive countermeasures, and create innovative solutions to the security issues that face the Pfizer environment.

The Senior Manager – Response Threat Operations will have demonstrated aptitude to rapidly apply expertise in a complex business and technical environment with previous experience in investigations, analysis, and incident response. Strong business communication and project management skills are required to maintain effective internal and customer relationships.

In addition, this position is also responsible for developing appropriate security incident response actions and monitoring effectiveness metrics.

• Lead the AMER Response Threat Operations (RTO) team, providing strategic direction, operational oversight, and people leadership while fostering a high-performing, collaborative, and growth-oriented culture.
• Partner with Cyber Defense and CISO leadership to define and execute the long-term vision, strategy, and operational roadmap for threat detection, incident response, and cyber defense capabilities.
• Oversee 24x7 threat monitoring, incident response, and cyber intrusion analysis activities across global regions, ensuring effective identification, investigation, containment, and remediation of security threats.
• Drive operational excellence through process optimization, automation, metrics-driven decision making, and continuous improvement initiatives that enhance response capabilities and organizational resilience.
• Lead and develop talent through performance management, coaching, mentoring, workforce planning, hiring, and career development, ensuring the team possesses the technical capabilities required to meet evolving threat landscapes.
• Serve as a key stakeholder and regional representative for Threat Operations, partnering with business, technology, and security leaders to manage risk, communicate security impacts, and strengthen organizational security posture.
• Direct the execution of strategic programs and projects using Agile principles, ensuring efficient resource management, timely delivery, and measurable business outcomes.
• Provide technical leadership and guidance on cyber threat detection, digital forensics, malware analysis, threat intelligence, and incident response methodologies while promoting continuous learning and cybersecurity expertise across the team.

• Bachelor's degree with 6+ years of experience, Master's degree with 5+ years of experience, or PhD with 1+ years of experience in cybersecurity, information security, computer science, or a related field.
• Advanced level understanding of TCP/IP, common networking ports and protocols, traffic flow, system administration, OSI model, defense-in-depth, and common security elements.
• Advanced level understanding of the life cycle of network threats, attacks, attack vectors and methods of exploitation with an understanding of intrusion set tactics, techniques, and procedures (TTPs)
• Advanced level knowledge of the Windows operating system, system utilities, admin functions
• Significant experience with open-source security analysis tools such…