Principal Scientist Oligonucleotide Process Development; Billerica MA

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the United States.

• Lead process development and synthesis strategies of ASOs, siRNAs and other synthetic modalities (100 mg‑5 g scale). Identify process improvements for better yield, purity, turnaround times and lower cost of goods.
• Work with a variety of oligonucleotide modalities (siRNAs, ASOs) and produce lipids, dyes, peptides and antibody conjugates.
• Apply strong laboratory skills in synthesis, purification, and characterization of antibody‑oligo conjugates.
• Analyze, interpret, and present data using current scientific literature and understanding of the state of the art in oligonucleotide chemistry, purification, and screening strategies. Apply state‑of‑the‑art analytical techniques such as UPLC, HPLC, LC‑MS and NMR.
• Collaborate with internal chemistry teams and external CROs to generate innovative solutions to synthetic and drug‑design challenges within the context of oligonucleotide drug‑discovery projects.
• Apply Design of Experiments (DoE) and Quality by Design (QbD) principles.
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.

• PhD in oligonucleotide chemistry and at least eight years of industry experience in drug‑discovery or process‑development environments involving oligonucleotide synthesis.

• Hands‑on experience with Akta SYNTH and OP‑100 and strong familiarity with Unicorn software.
• Excellent project and time‑management, and problem‑solving skills.
• Strong communication and interpersonal skills, with the ability to thrive in a team and goal‑driven environment.
• Proven track record of scientific contributions in oligonucleotide and conjugate research, evidenced by publications, presentations, patent applications, or identification of preclinical development candidates.

Billerica, MA

$129,000 – $193,400 per year. The actual compensation will vary based on location, level of experience, education, skills, and other job‑related factors. The position may be eligible for sales or performance‑based bonuses.

Health insurance, paid time off (PTO), retirement contributions, and other perquisites.